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Bietti crystalline corneoretinal dystrophy (BCD, MIM 210370) is a common form of hereditary retinal degeneration in the Chinese population. BCD is caused by CYP4V2 mutations. Understanding the CYP4V2 mutational spectrum and associated phenotypes is of value for clinical practice. In this study, nine CYP4V2 mutations, including four novel ones (c.215-2A>G,(More)
PURPOSE Mutations in tetraspanin 12 (TSPAN12) have recently been identified as a cause of autosomal dominant familial exudative vitreoretinopathy (FEVR). The purpose of this study was to detect TSPAN12 mutations in Chinese patients with FEVR and to describe the associated phenotypes. METHODS Sanger sequencing was used to analyze the seven coding exons and(More)
PURPOSE To investigate the safety of fluorescein angiography and to evaluate the examination. METHODS We retrospectively analyzed 8 344 patients who underwent fluorescein angiography in our hospital in the past four years. The rate of adverse events was calculated and the emergency management for severe cases was discussed. RESULTS There were 693 cases(More)
PURPOSE To characterize the appearance of the far peripheral retina of normal eyes using ultra-widefield fluorescein angiography (UWFA). DESIGN Cross-sectional study. METHODS This study enrolled 101 eyes with best-corrected visual acuity ≥20/20, with refractive error <3.00 diopters, and without visible retinal pathologic changes under a slit lamp-based(More)
PURPOSE To study the angiographic changes in the optic disc and its surrounding choroidoretina after optic nerve contusion with fundus fluorescein angiography (FFA), and indocyanine green angiography (ICGA). METHODS Thirty patients (30 eyes) with various degree of optic nerve damage caused by ocular contusion were examined with FFA and ICGA. (The(More)