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Neutrophil Elastase Activity Is Associated with Exacerbations and Lung Function Decline in Bronchiectasis
Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of endogenous elastin degradation, are possible biomarkers of disease severity and progression in bronchiectasis.Expand
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Identification of airway bacterial colonization by an electronic nose in Chronic Obstructive Pulmonary Disease.
BACKGROUND Airway bacterial colonization by potentially pathogenic microorganisms occurs in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases airwayExpand
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Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease Patients with Frequent Hospitalized Exacerbations: A Prospective Multicentre Study
Background: Pseudomonas aeruginosa (PA) is a common microorganism related to severe exacerbations in Chronic Obstructive Pulmonary Disease (COPD). However, their role in COPD patients with frequentExpand
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Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease
&NA; Figure. No caption available. Background: Neutrophil extracellular traps (NETs) have been observed in the airway in patients with chronic obstructive pulmonary disease (COPD), but their clinicalExpand
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Pseudomonas aeruginosa resistance patterns and clinical outcomes in hospitalized exacerbations of COPD
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) due to Pseudomonas aeruginosa (PA) are associated with worse outcomes. PA antibiotic resistance is important to determineExpand
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Salivary immunity and lower respiratory tract infections in non-elite marathon runners
Rationale Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationshipExpand
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Muscle MRI Findings in Childhood/Adult Onset Pompe Disease Correlate with Muscle Function
Objectives Enzyme replacement therapy has shown to be effective for childhood/adult onset Pompe disease (AOPD). The discovery of biomarkers useful for monitoring disease progression is one of theExpand
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Antimicrobial peptides, disease severity and exacerbations in bronchiectasis
Rationale Recently a frequent exacerbator phenotype has been described in bronchiectasis, but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are important in hostExpand
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Secreted mucins and airway bacterial colonization in non‐CF bronchiectasis
Secreted mucins play a key role in antibacterial defence in the airway, but have not previously been characterized in non‐cystic fibrosis (CF) bronchiectasis patients. We aim to investigate theExpand
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Diagnostic challenges of bronchiectasis.
Bronchiectasis is a condition of increasing incidence and prevalence around the world. Many different diseases have been associated with bronchiectasis, and their treatment can differ widely. RecentExpand
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