Guillermo Klein

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Opioids are extensively used analgesics yet can paradoxically increase pain sensitivity in humans and rodents. This hyperalgesia is extensively conceptualized to be a consequence of opioid receptor activity, perhaps providing an adaptive response to analgesia, and to utilize N-methyl-D-aspartate (NMDA) receptors. These assumptions were tested here in opioid(More)
Chronic exposure to opioids leads to physical dependence, which manifests as the symptoms of drug withdrawal. Interindividual differences in withdrawal symptom severity are well known, and at least partially due to genetic variation. To identify genes contributing to variation in withdrawal severity, we chronically treated 30 strains of the AcB/BcA(More)
We currently present the advanced development of our 12-lead ECG analyzing program HES. Recently our algorithm did not differentiate between atrial fibrillation or atrial flutter. Therefore, we now present a refined method for discrimination between atrial flutter and atrial fibrillation. The new approach contains two steps. In step one an algorithm has(More)
Overview: In driving hES cell technology towards widespread applications considerable effort has been focused on the improvement of culture conditions and on enabling efficient differentiation. We have established two technologies which will better enable researchers to achieve these aims. The use of feeder based protocols for the creation, expansion and(More)
Heart and vascular endothelial cells from human pluripotent stem cells are of interest for applications in cell therapy and cardiovascular disease. Differentiation protocols are now sufficiently refined that production of cardiomyocytes, endothelial-and smooth muscle cells is fairly efficient and reproducible. Genetically marked hESCs have been produced in(More)
Human (including clinical) cytogenetics theme of the report must be within the investigative section listed for that Editor. Manuscripts should be sent to Dr. H.P. Klinger at the Editorial Office only when their content does not match any of the listed sections. Any uncertainties can be clarified by writing to. or telephoning, Dr. Klin-ger at (212)(More)
NOTES – The opinions expressed in this document are those of the author and do not necessarily reflect those of ITU or its membership. The terms and definitions used are those of the author and in no way replace the official ITU definitions. ____________________ 1 Based on the responses to the questionnaire that was circulated to administrations and on(More)
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