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Akt/PKB: one kinase, many modifications.
Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals andExpand
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DNA Damage-induced Heterogeneous Nuclear Ribonucleoprotein K SUMOylation Regulates p53 Transcriptional Activation*
Background: hnRNP K acts as a p53 cofactor upon DNA damage. Results: DNA damage stimulates hnRNP K sumoylation, and this modification is required for p53 target gene expression. Conclusion: hnRNP KExpand
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Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors
Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exonExpand
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Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing.
Rac1b is an alternatively spliced isoform of the small GTPase Rac1 that includes the 57-nucleotide exon 3b. Rac1b was originally identified through its over-expression in breast and colorectal cancerExpand
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The serine/arginine-rich protein SF2/ASF regulates protein sumoylation
Protein modification by conjugation of small ubiquitin-related modifier (SUMO) is involved in diverse biological functions, such as transcription regulation, subcellular partitioning, stressExpand
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Modulation of the Akt Pathway Reveals a Novel Link with PERK/eIF2α, which Is Relevant during Hypoxia
The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathwaysExpand
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Regulating the regulators: serine/arginine-rich proteins under scrutiny.
Serine/arginine-rich (SR) proteins are among the most studied splicing regulators. They constitute a family of evolutionarily conserved proteins that, apart from their initially identified and deeplyExpand
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Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle
Akt/PKB is a key signaling molecule in higher eukaryotes and a crucial protein kinase in human health and disease. Phosphorylation, acetylation, and ubiquitylation have been reported as importantExpand
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The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing
Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel functionExpand
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SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
Abstract Pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein machine. Previous work from our laboratory revealed the splicing factor SRSF1 as a regulator of theExpand
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