Guillermo Aparicio

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Guillermo APARICIO, Leocadio G. CASADO2∗, Eligius M.T. HENDRIX, Boglárka G.-TÓTH, Inmaculada GARCIA 1Research Group TIC146: High Performance Computing – Algorithms University of Almería, Spain 2Informatics Department, University of Almería (ceiA3), Spain 3Department of Computer Architecture, Universidad de Málaga, Spain 4Department of Differential(More)
In several areas like global optimization using branch-and-bound methods for mixture design, the unit n-simplex is refined by longest edge bisection (LEB). This process provides a binary search tree. For n > 2, simplices appearing during the refinement process can havemore than one longest edge (LE). The size of the resulting binary tree depends on the(More)
Chitosan is a natural polymer with excellent properties such as biocompatibility, biodegradability, non-toxicity and adsorptive abilities. We obtained chitosan derived from Panurilus argus lobster shell and its lactate and acetate salts to introduce in pharmaceutical industry. We examined the single and repeated dose toxicity of chitosan and its lactate and(More)
Branch-and-Bound (B&B) algorithms to solve Global Optimization (GO) may use n-simplicial partition sets. The n-simplex represents an n-dimensional body with n+1 vertices in (n+1)-dimensional space. The aim of this article is to investigate the properties of the binary tree generated by iterative bisection of the longest edge (LE) of the regular(More)
Resumen Context: Despite the great mortality and morbidity of stroke, treatment options remain limited. We previously showed that JM-20, a novel synthetic molecule, possessed a strong neuroprotective effect in rats subjected to transient middle cerebral artery occlusion. However, to verify the robustness of the pre-clinical neuroprotective effects of JM-20(More)
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