Guillaume Saint-Lorant

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BACKGROUND Administration of cisplatin requires hyperhydration of the patient to prevent nephrotoxic effects of this molecule. MATERIALS AND METHODS A survey done in different hospitals - university hospitals, general hospitals and cancer institutes--has shown a large variability in the hydration protocols. A multidisciplinary group was set up in our(More)
PURPOSE We determined the prevalence of ESBL Enterobacteriaceae in urinary tract infections among inpatients, identified risk factors of acquisition, and evaluated the effectiveness of alternatives to carbapenems. METHODS The clinical, microbiological, and therapeutic data as well as the outcomes were recorded for all ESBL-E positive urine samples for(More)
Background Treatment of Gram-positive pathogens remains a major health issue due to the presence of methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus spp. Daptomycin offers an alternative after therapeutic failure using glycopeptides. Yet its use requires strict control given its financial impact and environmental(More)
Background Since 2002, linezolid, the first representative of the oxazolidinone class, has been widely prescribed, sometimes outside of approved indications. However, several cases of clinical outbreaks due to linezolid-resistant organisms have been reported, and its relatively high cost represents an economic challenge for hospital settings. Objectives The(More)
AIM Adverse drug events are a daily concern in neonatology departments. The aim of this study was to assess the professional practices of preparation and administration of injectable forms of medications in neonatology. MATERIALS AND METHODS A professional practice evaluation with regard to the preparation and administration of various injectable forms of(More)
The safety of patient care entails complying with the temperature requirements for thermosensitive drugs. Field studies carried out at the CHU de Caen University Hospital have demonstrated that patients and caregivers do not understand the critical aspect of thermosensitive drugs. This observation has led to the development of tools designed to secure the(More)
BACKGROUND During hyperthermic intraperitoneal chemotherapy (HIPEC), caregivers are exposed by different routes to cytotoxic drugs. This review proposes an overview of the safety of HIPEC by assessing existing data on protection procedures, biological and non-biological samples. Based on these data, relevant good practices, eventual irrelevant(More)
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