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Sleep is a fundamental biological process conserved across the animal kingdom. The study of how sleep regulatory networks are conserved is needed to better understand sleep across evolution. We present a detailed description of a sleep state in adult zebrafish characterized by reversible periods of immobility, increased arousal threshold, and place(More)
During gastrulation, dramatic movements rearrange cells into three germ layers expanded over the entire embryo [1-3]. In fish, both endoderm and mesoderm are specified as a belt at the embryo margin. Mesodermal layer expansion is achieved through the combination of two directed migrations. The outer ring of precursors moves toward the vegetal pole and(More)
Activity of zebrafish hoxb4a in the developing brain was analyzed in comparison to hoxa4a and hoxd4a using unique enhancer detection transgenes. Cytoplasmic YFP revealed shape and axonal projections of neurons in animals with insertions near the Hox4 genes and provided a means for the identification of neuronal subtypes. Despite an early activity of the(More)
The EGF-CFC factor Oep/Cripto1/Frl1 has been implicated in embryogenesis and several human cancers. During vertebrate development, Oep/Cripto1/Frl1 has been shown to act as an essential coreceptor in the TGFbeta/Nodal pathway, which is crucial for germ layer formation. Although studies in cell cultures suggest that Oep/Cripto1/Frl1 is also implicated in(More)
Objective The aim of this work is to identify the functions of the ciliary gene Rpgrip1l/Ftm in neurogenesis in the cerebral cortex. Rpgrip1l/Ftm encodes a protein enriched at the ciliary transition zone and is involved in ciliopathies with associated brain abnormalities, Meckel and Joubert syndromes. We have previously shown that Rpgrip1l is required for(More)
dered if guidance cue-induced changes in NFPC protein synthesis may play a role here. Interestingly, stimulating cultured growth cones with Sema3A, a repellent molecule expressed in telence-phalic regions adjacent to the MOT, elevates NFPC protein twofold within 10 min. Therefore, we now postulate a growth cone turning mechanism involving Sema3A-induced(More)
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