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ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in Cytokinesis
BACKGROUND Recent work has highlighted the importance of the recycling of endocytic membranes to the intercellular bridge for completion of cytokinesis in animal cells. ADP-ribosylation factor 6Expand
ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion
Interaction of plasma membrane ARF6 with JIP3/JIP4 effectors on MT1-MMP endosomes coordinates dynactin–dynein and kinesin-1 activity in a tug-of-war mechanism for endosome tubulation and MT1-MMPExpand
Recycling endosome tubule morphogenesis from sorting endosomes requires the kinesin motor KIF13A.
Early endosomes consist of vacuolar sorting and tubular recycling domains that segregate components fated for degradation in lysosomes or reuse by recycling to the plasma membrane or Golgi. TheExpand
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells.
Proteolytic degradation of the extracellular matrix by metastatic tumor cells is initiated by the formation of invadopodia, i.e., actin-driven filopodia-like membrane protrusions endowed withExpand
Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling
Supplying power: Right time, right place Cell membranes are very flexible and easily molded to shape; however, to physically pinch off a membrane vesicle from a membrane tube still requires power. AExpand
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4
The JNK‐interacting proteins, JIP3 and JIP4, are specific effectors of the small GTP‐binding protein ARF6. The interaction of ARF6–GTP with the second leucine zipper (LZII) domains of JIP3/JIP4Expand
Endocytic traffic in animal cell cytokinesis.
Cytokinesis is the final step of mitosis whereby two daughter cells physically separate. It is initiated by the assembly of an actomyosin contractile ring at the mitotic cell equator, whichExpand
Causes and Consequences of Microtubule Acetylation
Among the different types of cytoskeletal components, microtubules arguably accumulate the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 (K40) of α-tubulinExpand
Decoupling of Activation and Effector Binding Underlies ARF6 Priming of Fast Endocytic Recycling
The small GTP-binding protein ADP-ribosylation factor 6 (ARF6) controls the endocytic recycling pathway of several plasma membrane receptors. We analyzed the localization and GDP/GTP cycle ofExpand
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.
Invasive tumor cells use proteases to degrade and migrate through the stromal environment consisting of a 3D network of extracellular matrix macromolecules. In particular, MT1-MMP, aExpand