Guillaume Dufour

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Intravenous (i.v.) paracetamol is used as 1-g infusions with a maximal daily dose of 4 g/day. However, a higher initial analgesic dose could be of interest in the immediate postoperative period when the pain is maximal. The purpose of the present study was to determine in healthy subjects the safety and the pharmacokinetics of i.v. paracetamol, starting(More)
OBJECTIVE The aim of the present study was to assess the influence of preoperative statin therapy on postoperative mortality in high-risk patients after isolated valve surgery. DESIGN An observational cohort study. SETTING A 1,200-bed university hospital. PARTICIPANTS All consecutive patients undergoing isolated nonemergent valve surgery with(More)
The widespread use of man-made mineral fibres (MMMF) as insulation products in buildings can be a potential source of indoor pollution, but few data are available. Pollution levels were determined at 79 indoor and 18 outdoor locations. The standardized method (membrane filter method) was adapted to the environmental settings: 10 m3 of air was sampled over a(More)
INTRODUCTION Persistent peritonitis is a frequent complication of secondary peritonitis requiring additional reoperations and antibiotic therapy. This situation raises specific concerns due to microbiological changes in peritoneal samples, especially the emergence of multidrug-resistant (MDR) strains. Although this complication has been extensively studied,(More)
We recently documented the neutrophil response to enterovirulent diffusely adherent Escherichia coli expressing Afa/Dr fimbriae (Afa/Dr DAEC), using the human myeloid cell line PLB-985 differentiated into fully mature neutrophils. Upon activation, particularly during infections, neutrophils release neutrophil extracellular traps (NETs), composed of a(More)
Measurement-based approaches with extreme value worst-case estimations are beginning to be proficiently considered for timing analyses. In this paper, we intend to make more formal extreme value theory applicability to safe worst-case execution time estimations. We outline complexities and challenges behind extreme value theory assumptions and parameter(More)
BACKGROUND We assessed the clinical features and outcome of morbidly obese patients admitted to the intensive care unit (ICU) for management of postoperative peritonitis (POP) following bariatric surgery (BS). METHODS In a prospective, observational, surgical ICU cohort, we compared the clinical features, empiric antibiotic therapy, and prognosis of BS(More)
OBJECTIVE To compare the oxidative stress induced by IV iron infusion in critically ill patients and in healthy volunteers. DESIGN Multicenter, interventional study. SETTING Two ICUs and one clinical research center. SUBJECTS Anemic critically ill patients treated with IV iron and healthy volunteers. INTERVENTIONS IV infusion of 100 mg of iron(More)
Extracorporeal membrane oxygenation (ECMO) improves the outcome of refractory cardiogenic shock. Few studies in adult populations have specifically addressed the complications of ECMO. Abdominal compartment syndrome (ACS) has been previously described in the pediatric literature, but it has never been directly attributed to ECMO alone. The authors describe(More)
An atypical pattern of pericardial cyst was observed on a routine chest radiograph of a healthy 25-year-old woman. It appeared as an important elevation of the right diaphragm. The cystic nature of the mass was easily disclosed by ultrasonography and computed tomography, but its location--thoracic, diaphragmatic, or subphrenic--remained questionable.(More)