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Intravenous (i.v.) paracetamol is used as 1-g infusions with a maximal daily dose of 4 g/day. However, a higher initial analgesic dose could be of interest in the immediate postoperative period when the pain is maximal. The purpose of the present study was to determine in healthy subjects the safety and the pharmacokinetics of i.v. paracetamol, starting(More)
OBJECTIVE The aim of the present study was to assess the influence of preoperative statin therapy on postoperative mortality in high-risk patients after isolated valve surgery. DESIGN An observational cohort study. SETTING A 1,200-bed university hospital. PARTICIPANTS All consecutive patients undergoing isolated nonemergent valve surgery with(More)
Measurement-based approaches with extreme value worst-case estimations are beginning to be proficiently considered for timing analyses. In this paper, we intend to make more formal extreme value theory applicability to safe worst-case execution time estimations. We outline complexities and challenges behind extreme value theory assumptions and parameter(More)
We recently documented the neutrophil response to enterovirulent diffusely adherent Escherichia coli expressing Afa/Dr fimbriae (Afa/Dr DAEC), using the human myeloid cell line PLB-985 differentiated into fully mature neutrophils. Upon activation, particularly during infections, neutrophils release neutrophil extracellular traps (NETs), composed of a(More)
Exposure to asbestos was evaluated in 131 patients with pleural malignant mesothelioma in the Paris area between 1986 and 1992 using data from a detailed specific questionnaire and light microscopy analysis of the retention of asbestos bodies in bronchoalveolar lavage fluid or lung tissue. Probable or definite exposure to significant levels of asbestos dust(More)
INTRODUCTION Persistent peritonitis is a frequent complication of secondary peritonitis requiring additional reoperations and antibiotic therapy. This situation raises specific concerns due to microbiological changes in peritoneal samples, especially the emergence of multidrug-resistant (MDR) strains. Although this complication has been extensively studied,(More)
Extracorporeal membrane oxygenation (ECMO) improves the outcome of refractory cardiogenic shock. Few studies in adult populations have specifically addressed the complications of ECMO. Abdominal compartment syndrome (ACS) has been previously described in the pediatric literature, but it has never been directly attributed to ECMO alone. The authors describe(More)
Accepted 12 July 1993 Abstract Exposure to asbestos was evaluated in 131 patients with pleural malignant mesothelioma in the Paris area between 1986 and 1992 using data from a detailed specific questionnaire and light microscopy analysis of the retention of asbestos bodies in bronchoalveolar savage fluid or lung tissue. Probable or definite exposure to(More)
In north-east Corsica, asbestos outcrops are a source of environmental pollution, as assessed by airborne concentrations of chrysotile and tremolite that are significantly higher in the north-east than the north-west. For this reason we compared the frequencies of patients with asbestos pleural plaques in these 2 regions by checking the X-rays of 1721(More)
Asbestos fibers have been counted, using the transmission electron microscope, in 42 wines from France and abroad. 15 samples were found to be significantly positive for chrysotile asbestos. Concentrations were in the range of 2 to 60 x 10(6) fibers/liter. Technical inquiries have shown that the asbestos content of the wines was related to the process by(More)