Guillaum Hebert

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MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces diminution of the dopamine in nigrostriatal pathway and cognitive deficits in mice. MPTP treatment also increases pro-inflammatory cytokine production in substantia nigra and striatum. Since, pro-inflammatory cytokines influence striatal dopamine content and provoke cognitive impairments, the(More)
Previous studies have shown that morphine, injected into the substantia nigra of rats, had an antinociceptive effect on the tail-flick test. However, due to a transient behavioral stimulant effect of morphine, given intranigrally, valid tail-flick latencies cannot be obtained prior to 30 min after the injection into the nigra. In order to examine the effect(More)
As a follow-up from a previous study, four subjects taking a 6-week French language immersion program maintained a dream diary starting 2 weeks before until 2 weeks after the course. They also slept in the laboratory during four series of nights: one before the course, two during the course and one after the course. Confirming previous observations, it was(More)
The validity and reliability of hand-held dynamometry and Cybex dynamometry were investigated using maximal isometric contractions of the external rotators of the shoulder in 14 healthy male subjects. Three maximum voluntary contractions were recorded from each subject by a hand-held dynamometer and a Cybex isokinetic dynamometer at two testing sessions(More)
Rats were given daily injections of increasing doses of morphine sulfate (40-100 mg/kg, s.c.), for 4 days. Twenty hours after the last injection of morphine, the animals received bilateral injections of naloxone (1-10 micrograms) into the substantia nigra, ventral tegmental area or sites 2 mm rostral, caudal or dorsal to the site in the nigra. Withdrawal(More)
OBJECTIVE To describe and compare general practitioners' (GPs) opinions on antidepressant drugs and their prescriptions to depressed patients. METHOD Between November 2000 and July 2001 a representative sample of French GPs was asked their opinion of the 15 most prescribed antidepressants, and then to describe the treatments of the current depressive(More)
BACKGROUND The Saguenay-Lac-Saint-Jean (SLSJ) region is a geographically isolated area (population 285,955) located in the Northeastern part of the Province of Quebec, Canada. Using a population-based register, the genealogical reconstruction of 502 individuals with ruptured intracranial aneurysm (RIA) showed a familial aggregation (the presence of aneurysm(More)
Bilateral intranigral microinjection of morphine produces dose-related and naloxone reversible analgesic-like effects on the hot-plate and tail-flick tests. The main objectives of the present studies were to further characterize the analgesic-like effects of intranigral morphine, to determine whether these effects were related to a general impairment of(More)
This study was conducted to characterize the temporal relationship between intranigral injection of morphine and the onset of antinociception. The principal findings are: 1) morphine produces antinociception on the hot plate test within three minutes after intranigral injection, 2) the tail flick reflex cannot be measured within the first 30 minutes(More)
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