Guillame Churlaud

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fusion, MLL-PTDs, and/or mutations in IDH1 or IDH2. In sum, our data suggest that a wider spectrum of AMLs may be responsive to DOT1L inhibitors than originally predicted. While the observed responses of AML samples with MLL-PTDs or the PICALMMLLT10 fusion were anticipated, the responses of IDH-mutant samples were not. The neomorphic enzymatic activity of(More)
Follicular regulatory T (Tfr) cells from lymph node germinal centers control follicular helper T (Tfh) cell-dependent B cell activation. These scarce cells, often described and purified as CD25+ cells, are thought to be derived from thymic regulatory T (Treg) cells. However, we observed that mouse Tfr cells do not respond to interleukin-2 (IL-2), unlike(More)
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