Guilherme M. Sant'Anna

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We asked to what extent differences in caloric intake during the first postnatal weeks may modify thermal and respiratory control of 1-month old rats. Large-size (Large) and small-size (Small) rats were obtained by raising rats in, respectively, small (6 pups) and large (16 pups) litters. In Small, the rate of oxygen consumption (V(O(2))/kg) was less than(More)
OBJECTIVE Somatosensory evoked potentials (SEPs) are reported to have high positive predictive value (PPV) for neurodevelopmental impairment (NDI) in neonates with moderate or severe hypoxic-ischemic encephalopathy (HIE). Our objective was to assess if this predictive value remains high with the use of therapeutic hypothermia. METHODS A cohort of HIE(More)
This paper describes organizational guidelines and an anonymization protocol for the management of sensitive information in interdisciplinary, multi-institutional studies with multiple collaborators. This protocol is flexible, automated, and suitable for use in cloud-based projects as well as for publication of supplementary information in journal papers. A(More)
Extremely preterm infants (gestational age ≤ 28 weeks) often require EndoTracheal Tube-Invasive Mechanical Ventilation (ETT-IMV) to survive. Clinicians wean infants off ETT-IMV as early as possible using their judgment and clinical information. However, assessment of extubation readiness is not accurate since 20 to 40% of preterm infants fail extubation. We(More)
We present an approach for the analysis of clinical data from extremely preterm infants, in order to determine if they are ready to be removed from invasive endotracheal mechanical ventilation. The data includes over 100 clinical features, and the subject population is naturally quite small. To address this problem, we use feature selection, specifically(More)
Surfactant has revolutionized the treatment of respiratory distress syndrome and some other respiratory conditions that affect the fragile neonatal lung. Despite its widespread use, the optimal method of surfactant administration in preterm infants has yet to be clearly determined. The present article reviews several aspects of administration techniques(More)
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