Guilherme José Garcia Santos Pimenta

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1 Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL. Mol Psychiatry 2005; 10: 758–764. 2 Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R et al. Hum Mole Genet 2001; 10: 1611–1617. 3 Ekelund J, Hennah W, Hiekkalinna T, Parker A, Meyer J, Lonnqvist J et al. Mol Psychiatry 2004; 9: 1037–1041. 4 Macgregor S, Visscher PM, Knott SA,(More)
The occurrence of mania during antidepressant treatment is a key issue in the clinical management of bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of mood disorders. Moreover, antidepressants increase the expression of BDNF and its overactivity may be involved in the mechanism of development of the(More)
The aim of the present study was to examine the association between polymorphism in the catechol-O-methyltransferase(COMT) gene and Alzheimer's disease (AD) in a Brazilian population. The case-control method was used to study the association between AD and genetic variants of COMT. Six tag single-nucleotide polymorphisms(SNPs) in the COMT gene were(More)
We tested the hypothesis that the presence of AKT1 and AKTIP polymorphisms, target genes that encode key proteins in the signaling of dopaminergic and serotonergic systems, is associated with suicidal behavior in bipolar patients. The subjects were 273 patients diagnosed with bipolar disorder I or II (age = 41.4 +/- 12.9). TaqMan single-nucleotide(More)
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