Guilherme A. Senger

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BACKGROUND Intracellular proteins are processed into small peptides that bind HLA class I molecules of the major histocompatibility complex (MHC) in order to be presented to T lymphocytes. The proteasome, a multi-subunit protease, has recently been implicated in the generation of these peptides. Two genes encoding proteasome subunits, LMP2 and LMP7, are(More)
The molecular analysis of many genetic diseases requires the isolation of probes for defined human chromosome regions. Existing techniques such as the screening of chromosome-specific libraries, subtractive DNA cloning and chromosome jumping are either tedious or not generally applicable. Microdissection and microcloning has successfully been applied to(More)
We have developed techniques for chronic recording of electrocortical activity in the fetal and neonatal guinea pig with subsequent power spectral analysis. Thirty-four unanesthesized, unrestrained pregnant Hartley guinea pigs were studied 1 to 14 days following surgical procedures. Twelve neonatal animals instrumented during the first week of life were(More)
With the use of a relatively inexpensive microcomputer-based system for power spectral analysis, we have been able to provide quantitative information on maturational changes in electrocorticogram waveforms in the third-trimester fetal lamb. Twenty-six electrocorticogram recordings were obtained from nine fetal lambs, with gestational ages ranging from 114(More)
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