Guilherme A. Senger

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Fluorescence in situ hybridization (FISH) of microlibraries established from distinct chromosome subregions can test the evolutionary conservation of chromosome bands as well as chromosomal rearrangements that occurred during primate evolution and will help to clarify phylogenetic relationships. We used a DNA library established by microdissection and(More)
BACKGROUND Intracellular proteins are processed into small peptides that bind HLA class I molecules of the major histocompatibility complex (MHC) in order to be presented to T lymphocytes. The proteasome, a multi-subunit protease, has recently been implicated in the generation of these peptides. Two genes encoding proteasome subunits, LMP2 and LMP7, are(More)
The molecular analysis of many genetic diseases requires the isolation of probes for defined human chromosome regions. Existing techniques such as the screening of chromosome-specific libraries, subtractive DNA cloning and chromosome jumping are either tedious or not generally applicable. Microdissection and microcloning has successfully been applied to(More)
We have developed techniques for chronic recording of electrocortical activity in the fetal and neonatal guinea pig with subsequent power spectral analysis. Thirty-four unanesthesized, unrestrained pregnant Hartley guinea pigs were studied 1 to 14 days following surgical procedures. Twelve neonatal animals instrumented during the first week of life were(More)
Partial trisomy 9q represents a rare and heterogeneous group of chromosomal aberrations characterised by various clinical features including pyloric stenosis. Here, we describe the case of a 1 year old female patient with different dysmorphic features including pyloric stenosis and prenatally detected partial trisomy 9q. This partial trisomy 9q has been(More)
With the use of a relatively inexpensive microcomputer-based system for power spectral analysis, we have been able to provide quantitative information on maturational changes in electrocorticogram waveforms in the third-trimester fetal lamb. Twenty-six electrocorticogram recordings were obtained from nine fetal lambs, with gestational ages ranging from 114(More)
Females with XY gonadal dysgenesis are sterile, due to degeneration of the initially present ovaries into nonfunctional streak gonads. Some of these sex-reversal cases can be attributed to mutation or deletion of the SRY gene. We now describe an SRY-deleted 47,XXY female who has one son and two daughters, and one of her daughters has the same 47,XXY(More)
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