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Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization: access to CF3-containing 2-azaspiro[4.5]decanes.
Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization was achieved and used to regiospecifically construct a variety of trifluoromethylated
Copper-Catalyzed Trifluoromethylation of Ynones Coupled with Dearomatizing Spirocyclization of Indoles: Access to CF3-Containing Spiro[cyclopentane-1,3'-indole].
This cascade process enables constructing diverse CF3-containing spiro[cyclopentane-1,3'-indole] scaffolds in moderate to excellent yields which have challenging quaternary spirocyclic carbon and tetrasubstituted alkenes.
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
A mechanistic evaluation showed that 2-R potently inhibited cell growth and colony formation, which is associated with a delay in S phase progression through the inhibition of DNA synthesis, which will facilitate the discovery of new Phenanthroindolizidine and phenanthroquinolIZidine alkaloids for use as anticancer drug candidates.
Copper-mediated α-trifluoromethylation of N-phenylcinnamamides coupled with dearomatization: access to trifluoromethylated 1-azaspiro[4.5]decanes.
Copper-mediated intramolecular trifluoromethylation of N-phenylcinnamamides coupled with cyclization and dearomatization was used to construct 1-azaspiro[4.5]decanes in moderate to high yields and with excellent regioselectivities and diastereoselectivity.
Copper‐Catalyzed Trifluoromethylation of Acrylamides Coupled with Indole Dearomatization: Access to Trifluoromethyl‐Substituted Spiro[indole‐3,3′‐pyrrolidine] Derivatives
A copper-catalyzed cascade reaction involving trifluoromethylation of acrylamides coupled with ring closure and indole dearomatization is reported. This facile transformation was highly
Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids.
Propargyl quaternary ammonium salt compound S-7b showed the best anti-TMV activities both in vitro and in vivo in the laboratory and in the field trials of antiviral efficacy against TMV, and exhibited better activities than control plant virus inhibitors.