Guido Waldmann

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Abnormal phosphorylation of the tau-protein is regarded as a crucial step in the formation of neurofibrillary tangles in the neuronal cell body and neuropil threads in dendrites. We studied the effects of tau-pathology on the clinical expression of dementia in 106 autopsy cases in the entorhinal region, the hippocampal stratum oriens, the stratum radiatum,(More)
Neuromagnetic fields were recorded from the left cerebral hemisphere of six healthy right-handed subjects under three different conditions: (1) externally triggered rapid voluntary extension and flexion of the right hand, (2) passive extension and flexion of the right hand, and (3) stimulation of the skin of the right index finger by means of air pressure.(More)
In the course of antigen-induced arthritis of rabbit cell-mediated and humoral immune responses were repeatedly tested in order to prove their significance for the acute and chronic phase of inflammation. The arthritis was monitored during the progression of the inflammation by means of the joint swelling and at the end of experiments by histological(More)
The chronicity of the antigen-induced arthritis is characterized as dependent on the development of cell-mediated immunity to the antigen, but the exact mechanisms underlying are unclear. We have evidenced decreased suppressor and increased helper cell potential in the early phase of arthritis as result of the immunization procedure. In the late phase of(More)
Repetitive movements have been reported to induce task-specific changes of intracortical inhibition and facilitation, but the mechanism operating shortly after hand movement is unclear. Transcranial magnetic single and paired stimuli (2 ms) were applied to 15 healthy subjects at rest and 1 s after repetitive (every 6 s) active and passive hand extensions.(More)
In terminal Alzheimer's disease (AD) the frequency of plaques was found to be reduced in single cases. To test this finding in a larger sample, and in order to determine whether the number of plaques labeled with different markers and the distribution of neurofibrillary tangles are correlated positively to each other and to the degree of dementia, a sample(More)
OBJECTIVE To determine whether a repetitive training of complex movements of arm and hand contributes to functional recovery in stroke patients. DESIGN Prospective, longitudinal, multiple baseline design across individuals. SETTING Neurological rehabilitation centre. SUBJECTS Twenty-one patients with stroke in the middle cerebral artery territory. (More)
The serum of rats collected at various time intervals after application of a single dose of 2-acetylaminofluorene (AAF) stimulates the incorporation of 3H-thymidine into the DNA of cultured thymocytes of rats, mice and hamsters. This reaction shows a clear dose-response relationship. The serum activity is dialysable and relatively thermostable.
Experimentally induced arthritis models have been widely used in order to study and test antiinflammatory and antiarthritic drugs and, furthermore, to investigate pathogenic mechanisms of joint inflammation. Most of the chronic arthritides in animals are initiated immunologically, i.e. antigeninduced arthritis (AIA), adjuvant arthritis (AA) and collagen(More)