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Abnormal phosphorylation of the tau-protein is regarded as a crucial step in the formation of neurofibrillary tangles in the neuronal cell body and neuropil threads in dendrites. We studied the effects of tau-pathology on the clinical expression of dementia in 106 autopsy cases in the entorhinal region, the hippocampal stratum oriens, the stratum radiatum,(More)
Neuromagnetic fields were recorded from the left cerebral hemisphere of six healthy right-handed subjects under three different conditions: (1) externally triggered rapid voluntary extension and flexion of the right hand, (2) passive extension and flexion of the right hand, and (3) stimulation of the skin of the right index finger by means of air pressure.(More)
OBJECTIVE To determine whether a repetitive training of complex movements of arm and hand contributes to functional recovery in stroke patients. DESIGN Prospective, longitudinal, multiple baseline design across individuals. SETTING Neurological rehabilitation centre. SUBJECTS Twenty-one patients with stroke in the middle cerebral artery territory. (More)
In terminal Alzheimer's disease (AD) the frequency of plaques was found to be reduced in single cases. To test this finding in a larger sample, and in order to determine whether the number of plaques labeled with different markers and the distribution of neurofibrillary tangles are correlated positively to each other and to the degree of dementia, a sample(More)
Repetitive movements have been reported to induce task-specific changes of intracortical inhibition and facilitation, but the mechanism operating shortly after hand movement is unclear. Transcranial magnetic single and paired stimuli (2 ms) were applied to 15 healthy subjects at rest and 1 s after repetitive (every 6 s) active and passive hand extensions.(More)
The serum of rats obtained at various time intervals after administration of AAF was tested for its action on the 3H-thymidine incorporation into the DNA of thymocytes in vitro. In comparison with untreated or solvent-treated controls, the sera of animals in the early phase after the AAF-treatment stimulate the incorporation of the nucleotide into the(More)
Different Antibody tests (IgG, IgM) were made from children with chronical and recurrent urinary tract infections with help of the indirect fluorescent method and were compared with the indirect hemagglutination test. The indirect hemagglutination gave absolutely higher antibody rest results, but the specifity of the immune fluorescence test is just as(More)
Lipopolysaccharide binding sites of guinea pig peritoneal macrophages were demonstrated by means of immunogold technique. Resident peritoneal macrophages show a strong specific binding of bacterial lipopolysaccharides from E. coli to cell surface structures.
In 150 patients with an acute cerebrovascular insufficiency we asked the following questions: 1. How often appear together the cardiac decompensation and disturbances of cardiac rhythm, 2. symptoms of hypertrophy and disturbances of cardiac rhythm and 3. arteriosclerosis of the cerebral and coronary vessels in deceased patients. The number of patients(More)