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The localization of 5-hydroxytryptamine1B receptors in the rat central nervous system was investigated using anti-peptide antibodies that recognize a selective portion of the third intracytoplasmic loop of the receptor protein. At the light microscope level the densest 5-hydroxytryptamine1B receptor-like immunoreactivity was observed in ventral pallidum,(More)
In an effort to assess the innate capacity of the central visual system to specify corticocortical connectivity in the absence of retinal afferents, we examined the tangential distribution of callosal cells and terminations in posterior neocortex of congenitally anophthalmic rats. Although our results indicate that the callosal pattern is clearly anomalous(More)
Animal models of neuropathic pain involving incomplete nerve injury result in causalgia-like symptoms, including thermal hyperalgesia and mechanical allodynia. Although current evidence links the overexpression of nerve growth factor (NGF) to peripheral neuropathic pain, the direct effect of NGF inside a nerve has not been evaluated yet. The purpose of this(More)
Recent findings indicate that calcitonin gene-related peptide (CGRP) is involved in neuropathic pain, this peptide being up-regulated in a small population of large- and medium-sized primary sensory neurons after peripheral nerve injury. In adult animals, the expression of CGRP is regulated by nerve growth factor (NGF). After nerve injury, NGF is(More)
—With the growing number of researchers interested in modeling the inner workings of affective social intelligence, the need for tools to easily model its associated expressions has emerged. The goal of this article is twofold: 1) we describe HapFACS, a free software and API that we developed to provide the affective computing community with a resource that(More)
Endoneurial nerve growth factor (30 ng) produced significant heat hyperalgesia in rats on postinjection days 3 and 5. The percentage of neuron profiles expressing the sensory neuropeptide substance P in the dorsal root ganglion (DRG), and the density and distribution of substance P immunoreactivity at the DRG and the dorsal horn remained essentially(More)
The distribution of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors in the visual cortex was studied by quantitative autoradiography during postnatal development. Overall, receptor densities increased throughout development, but exhibited regional rearrangements, particularly in the case of 5-hydroxytryptamine1B receptors. Neonatal treatment with(More)
The effects of chronic treatment with phenytoin (50 mg/kg p.o. daily, for the first 30 days after birth) on GABAA and beta-adrenoceptors in the rat cerebellum were investigated by using in vitro quantitative autoradiography and binding assays with membranes. A significant decrease in [3H]muscimol binding to GABAA sites and, to a lesser extent,(More)
Phenytoin (PH) is commonly used as an anticonvulsant drug, and it causes several collateral effects including morphological changes in brain cortex neurons and teratogenic lesions in infants of epileptic mothers. Several lines of evidence indicate that PH may exert its action through the modification of phosphorylation patterns of neuronal polypeptides. We(More)
We are interested in the expression of synapse-specific macromolecules and its correlation with the appearance of neuronal types and synaptogenesis during development of the mammalian brain. We report here studies showing that the appearance of acetylcholinesterase (AChE) at layer IV of the rat somatosensory cortex is correlated with the expression of a(More)