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By using electrophysiological and microfluorimetric methods, we found that leech Retzius neurons swell after inhibition of the Na+–K+ pump by the cardiac glycoside ouabain. To explore the mechanism of this swelling, we measured the effect of ouabain on [Na+]i, [K+]i, and [Cl−]i, as well as on the membrane potential, by applying triple-barrelled(More)
In leech P neurons the inhibition of the Na+-K+ pump by ouabain or omission of bath K+ leaves the membrane potential unaffected for a prolonged period or even induces a marked membrane hyperpolarization, although the concentration gradients for K+ and Na+ are attenuated substantially. As shown previously, this stabilization of the membrane potential is(More)
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