Guido Bossi

Learn More
BACKGROUND The incidence of both melanoma and nonmelanocytic skin cancers has risen dramatically during the past decades, skin cancer becoming an important public health concern. OBJECTIVE The purpose of this study was to assess the ability of general practitioners (GPs) in the early diagnosis of skin cancers, their correct differential diagnosis of(More)
BACKGROUND Cytomegalovirus (CMV) infection has been correlated with various autoimmune disorders. Using molecular biology techniques, DNA sequences of CMV have been reported in paraffin sections of alopecia areata (AA) lesions. Reactivation of the CMV infection has been postulated as one of the pathogenic mechanisms in AA. Other studies, using different(More)
Psoriasis has been associated with an abnormal plasma lipid metabolism, and changes of erythrocyte membrane lipid composition and fluidity have been shown in adult patients. To investigate whether the alterations of plasma lipids appear also in pediatric patients, we have studied plasma lipids and lipoproteins in 15 prepubertal children affected by(More)
Plasma lipid, lipoprotein and apoprotein concentrations were determined in psoriatic children and in healthy controls. The plasma total cholesterol (TC) was higher than in controls (p = 0.03). The higher cholesterol levels were explained by an almost significant increase in cholesterol associated with high-density lipoproteins and by the tendency towards(More)
Psoriasis, a chronic inflammatory skin disease characterized by an aberration of lipid metabolism, has been associated with an increased risk for atherosclerosis. Since oxidatively modified lipoproteins are involved in the pathogenesis of atherosclerosis, we investigated the lipid composition and in vitro induced peroxidation of very low density(More)
After the isolation of two Vibrio cholerae NAG from the stools of two tourists, the authors researched Vibrio in people coming home from particular countries and in resident people. The research was extended to the water of Varese lake after another isolation from a fisher who had fished, cooked and eaten the lake fish. Problems concerning the(More)
We have studied the lipoprotein chemical composition and fluidity, using the fluorescence polarization of the probe 1,6-diphenyl-1,3,5-hexatriene (DPH) in two age- and sex-matched groups of subjects (14 healthy normolipidemic children and 15 psoriatic children). The compositional study has shown a significant increase of the percentage content in(More)
We studied membrane fluidity in living polymorphonuclear leukocytes and in erythrocytes of 8 psoriatic patients, using fluorescence polarization of 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene. In erythrocyte membranes of psoriatic patients we observed a decrease of fluidity, these changes were not associated to relevant modifications of the(More)