Gui-zhen Zhao

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AIM To explore the mechanism of intra-uterine transmission, the HBV infection status of placental tissue and in vitro cultured placental trophoblastic cells was tested through in vivo and in vitro experiments. METHODS A variety of methods, such as ELISA, RT-PCR, IHC staining and immunofluorescent staining were employed to test the HBV marker positive(More)
OBJECTIVE To study the role of tumor necrosis factor-alpha (TNFalpha) and caspase-3 expression on hepatocyte apoptosis in experimental model of fulminant hepatic failure (FHF). METHODS Mouse experimental model of FHF was induced by lipopolysaccharide (LPS) and D-galactosamine (D-GalN). Serum TNFalpha level and TNFalpha mRNA expression in liver were tested(More)
Iodine depletion prevents disease and iodine repletion, which may cause thyroid cell injury by reactive oxygen intermediates, initiates disease in the Obese Strain chicken model of spontaneous autoimmune thyroiditis (AT). To examine the role of cell injury and autoantigen availability in AT induction we compared the immune responses that followed blunt(More)
BACKGROUND This study was undertaken to investigate the predictive factors of sustained viral response in roferon-A or pegasys treated chronic hepatitis C patients after logistic regression analysis of the factors that might be associated with the therapeutic effects of interferon (IFN). METHODS All patients enrolled into this randomized, open and(More)
In 54 anesthetized rats, the changes in arterial blood pressure, heart rate and/or urine volume, urinary sodium excretion were observed following intracarotid, intrathecal and intracerebroventricular (ICV) injection of atrial natriuretic peptide (ANP). The effects of ANP on the central actions of angiotensin II (AG II) were also examined. The results were(More)
Application of atrial natriuretic peptides (alpha-ANP and AP III) to glutamate sensitive area of ventrolateral medulla produced a dose-dependent decrease in MAP and HR in anesthetized rats. Lower dosage of AP III induced hypotension without bradycardia, whereas the higher dosage of AP III decreased both blood pressure and heart rate. The results suggested(More)
The regional blood flow changes induced by intravenous injection of atriopeptin III (AP III) and the effects of intra-arterial injection of AP III on regional vascular resistance were investigated in 42 anesthetized rabbits. The results were as follows: (1) In anesthetized rabbits (n = 8), intravenous injection of AP III (30 micrograms/kg) resulted in a(More)
OBJECTIVE To evaluate the efficacy and investigate the influencing factors of the interferon (IFN) retreatment for patients with chronic hepatitis C relapsed after a previous IFN treatment. METHODS A retrospective study was designed to analyze the retreatment with IFN of 60 relapsed chronic hepatitis C patients. All patients were from a randomized, opened(More)