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The pharmacokinetics of azathioprine (AZA) and 6-mercaptopurine (6-MP) was studied in uremic patients after 100 mg AZA intravenously (fifteen patients) and orally (eight patients). 6-MP was analysed with gas chromatography mass spectrometry following extractive alkylation. AZA was determined indirectly assuming quantitative conversion to 6-MP in whole(More)
BACKGROUND In adults, it has been shown that the pharmacokinetics of doxorubicin are highly variable, despite standardization of the dose based on body surface area (BSA). The purpose of this study was to determine the plasma concentrations of doxorubicin and its active metabolite doxorubicinol in children treated for acute lymphoblastic leukemia (ALL). (More)
The levels of carbonic anhydrase (CA) activity and the amounts of carbonic anhydrase isoenzyme CA I and CA II proteins in the human gastrointestinal tract were determined by kinetic assays and radioimmunoassays. Cellular distribution of carbonic anhydrase activity in the various segments of the gastrointestinal tract were studied by the histochemical method(More)
Phenytoin excretion into human breast milk was studied in six nursing women with epilepsy. The average ratio between the areas under the plasma (and milk) concentration versus time curves (AUC) was 0.13. There was a good (r = 0.97) correlation between the mean plasma and milk concentrations of phenytoin, and an even better relation (r = 0.99) between the(More)
We retrospectively evaluated reticulin fiber density (RFD) in 166 diagnostic bone marrow (BM) biopsies and 62 biopsies obtained at treatment day 29 from children with acute lymphoblastic leukemia (ALL). Patients with B-cell precursor (BCP)-ALL showed higher RFD as compared to patients with T-cell ALL (P<0.001). RFD correlated negatively with white blood(More)
The distribution of carbonic anhydrase (CA) in the rabbit eye was studied by light and electron microscopy according to the histochemical method of Hansson. In the cornea, CA staining was found in the cytoplasm of the endothelium. The filtering tissue in the chamber angle did not stain. The pigmented epithelium of the iris and the non-pigmented epithelium(More)
The rat kidney was studied by light and electron microscope after it was histochemically stained for carbonic anhydrase activity. Glomeruli and Bowman's capsule were inactive. Convoluted proximal tubules showed intense activity at the brush border and the basolateral membranes. Cytoplasmic activity also was found. Straight proximal tubules had considerable(More)
The distribution of carbonic anhydrase activity in the intestinal tract of the guinea-pig was studied by the histochemical method of Hansson. Enzyme activity was demonstrated in epithelial cells, erythrocytes and capillary walls. In the gastric mucosa parietal cells, surface mucous cells and neck mucous cells were highly active. In the small intestine only(More)