Guanyu Wang

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A central challenge in systems biology today is to understand the network of interactions among biomolecules and, especially, the organizing principles underlying such networks. Recent analysis of known networks has identified small motifs that occur ubiquitously, suggesting that larger networks might be constructed in the manner of electronic circuits by(More)
Hypoxia induces the expression of genes that alter metabolism through the hypoxia-inducible factor (HIF). A theoretical model based on differential equations of the hypoxia response network has been previously proposed in which a sharp response to changes in oxygen concentration was observed but not quantitatively explained. That model consisted of(More)
BACKGROUND The dose-dependent toxicities of doxorubicin (DOX) limit its clinical applications, particularly in drug-resistant cancers, such as liver cancer. In this study, we investigated the role of quercetin on the antitumor effects of DOX on liver cancer cells and its ability to provide protection against DOX-mediated liver damage in mice. METHODOLOGY(More)
We present a simple and robust method for image and volume data segmentation based on manifold distance metrics. This is done by treating the image as a function that maps the 2D (image) or 3D (volume) to a 2D or 3D manifold in a higher dimensional feature space. We explore a range of possible feature spaces, including value, gradient, and probabilistic(More)
A common problem in molecular biology is to use experimental data, such as microarray data, to infer knowledge about the structure of interactions between important molecules in subsystems of the cell. By approximating the state of each molecule as "on" or "off", it becomes possible to simplify the problem, and exploit the tools of boolean analysis for such(More)
Wireless sensor networks are attracting much attention from the world and Minimum Latency Aggregation Scheduling(MLAS) has become one of the most significant fundamental problems in wireless sensor networks. However there are few results about efficient data aggregation algorithms under the Signal-to-Interference-plus-Noise-Ratio (SINR) model. In this(More)
The PI3K/Akt/mTOR pathway plays an essential role in a wide range of biological functions, including metabolism, macromolecular synthesis, cell growth, proliferation and survival. Its versatility, however, makes it a conspicuous target of many pathogens; and the consequential deregulations of this pathway often lead to complications, such as tumorigenesis,(More)