Guangzhen Zhong

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OBJECTIVE The present study intended to investigate whether the impaired H2S synthase/H2S pathway is associated with hypertension. METHODS Hypertension in Wistar rats was induced by the oral administration of the l-arginine analog, NG-nitro-l-arginine methyl ester (l-NAME) in their drinking water for a period of 6 weeks. The control rats were given plain(More)
OBJECTIVES To evaluate vascular endothelial function and contributing factors in coronary heart disease (CHD) patients. METHODS One hundred twenty six CHD outpatients were randomly recruited. Reactive hyperemia index (RHI) <1.67 indicates endothelial dysfunction. Correlation between RHI and different biochemical parameters was evaluated. RESULTS RHI in(More)
We studied the effects of cobalt-60 Γ-radiation on the gene expression and secretion of adrenomedullin (Adm) and endothelin (ET) in cultured rat vascular smooth muscle cells (VSMCs). Rat VSMCs cultured in Dulbecoo's modified Eagle's medium containing 10% FBS were radiated with cobalt-60 Γ-radiation at doses of 1, 14, and 25 Gy, respectively. Then the mRNA(More)
Both activities of daily living (ADL) and some blood biomarkers (such as albumin) have been associated with mortality in very elderly people, but scarce data is available on the predictive performance of them in isolation or in combination, which is important for clinicians in decision making. Here, based on prospective mortality data over a 6-year(More)
OBJECTIVE To observe the effect of adrenomedullin (ADM) on the production of nitric oxide (NO) in rat aorta and the effect of Proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on the ADM-induced NO production. METHODS Isolated aortic tissues were exposed to ADM, PAMP and ADT for 2 h. The NO production, indicated by nitrite content in(More)
BACKGROUND This study aimed to investigate the endothelial function by reactive hyperemia index (RHI) in patients with depression, subjects recovering from depression, and subjects without a history of depression. MATERIAL AND METHODS Outpatients were recruited from a general hospital in China; 62 patients diagnosed with depression and the 17-item(More)
The effects of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on adrenomedullin (ADM)-induced vasodilation were investigated in aortic rings from rat. ADM (10(-9) to 10(-7)M) relaxed the aorta preconstricted with phenylephrine in a concentration-dependent manner. Denudation of endothelium or pretreatment with nitric oxide synthase(More)
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