Guangyu Jin

  • Citations Per Year
Learn More
AIMS The present study is to investigate the effect of cornuside on mast cell-mediated allergic response, as well as its possible mechanisms of action. METHODS To test the anti-allergic effects of cornuside in vivo, local extravasation was induced by local injection of anti-dinitrophenyl immunoglobulin E (IgE) followed by intravenous antigenic challenge(More)
Polydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms in in vitro and in vivo models. IgE-mediated passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA) models were used to confirm PD effect in vivo. Various signaling pathway proteins in mast cell were examined. RT-PCR, ELISA and(More)
To determine the potential role of cornuside in the regulation of allergic airway inflammation in lipopolysaccharide (LPS) and ovalbumin (OVA)-induced asthma. BALB/c mouse model of LPS and OVA-induced asthma was used to evaluate the effect of cornuside on Toll-like receptor 4 (TLR4) and Nocth1 signaling pathway. Hematoxylin and eosin staining was performed(More)
OBJECTIVE To explore the protective effects and mechanism of ethanol extract of Inonotus obliquus (EEIO) injection on asthmatic mice. METHOD OVA was injected intraperitoneally and inhaled to produce the asthmatic model. Thirty two mice were randomly divided into four groups: control group, asthma group and I. obliquus groups of high and low dose. The(More)
  • 1