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The present study was designed to investigate the in vivo drug release and antibacterial properties of a novel mesoporous hydroxyapatite/chitosan (mesoHA-CS) composite loaded with vancomycin (VCM). VCM-mesoHA/CS composite was prepared via a freeze-drying method. The successful loading of VCM in the composite scaffold was verified by FT IR analyses. SEM… (More)
OBJECTIVE Inflammation is widely acknowledged to increase morbidity and mortality in myocardial infarction (MI), and the ideal therapeutic methods should be aimed at the inflammation reaction triggers. The aim was to evaluate the protective effect of saponins extracted from Panax japonicus (SPJ) on MI, and based on these results investigate the possible… (More)
We design, fabricate, and demonstrate a silicon nitride (Si(3)N(4)) multilayer platform optimized for low-loss and compact multilayer photonic integrated circuits. The designed platform, with 200 nm thick waveguide core and 700 nm interlayer gap, is compatible for active thermal tuning and applicable to realizing compact photonic devices such as arrayed… (More)
The wurtzite-derived Cu₂ZnSn(S(1-x)Se(x))₄ alloys are studied for the first time through combining theoretical calculations and experimental characterizations. Ab initio calculations predict that wurtzite-derived Cu₂ZnSnS₄ and Cu₂ZnSnSe₄ are highly miscible, and the band gaps of the mixed-anion alloys can be linearly tuned from 1.0 to 1.5 eV through… (More)
Recently, studies based on time-varying functional connectivity have unveiled brain states diversity in some neuropsychiatric disorders, such as schizophrenia and major depressive disorder. However, time-varying functional connectivity analysis of resting-state functional Magnetic Resonance Imaging (fMRI) have been rarely performed on the Autism Spectrum… (More)
We design Si3N4 tri-layer vertical Y-junction with arbitrary splitting ratio and low reflection, fabricate bi-layer asymmetric vertical coupler, and demonstrate tri-layer vertical Y-junction with splitting ratio of 1:1 and 3:2 for multilayer photonic integrated circuits.
We design, fabricate, and demonstrate ultra-low loss Si 3 N 4 vertical couplers for multilayer photonic integrated circuits. We achieve 0.05 dB coupling loss, 100×2 µm 2 footprint, and vertical coupling tolerant to lateral misalignment up to 1.2 µm. 1. Introduction Recent advances in photonic integrated circuits (PIC)  are accelerating positive prospects… (More)
We designed and demonstrated a tri-layer Si<sub>3</sub>N<sub>4</sub>/SiO<sub>2</sub> photonic integrated circuit capable of vertical interlayer coupling with arbitrary splitting ratios. Based on this multilayer photonic integrated circuit platform with each layer thicknesses of 150 nm, 50 nm, and 150 nm, we designed and simulated the vertical Y-junctions… (More)
This paper demonstrates rapidly reconfigurable, high-fidelity optical arbitrary waveform generation (OAWG) in a heterogeneous photonic integrated circuit (PIC). The heterogeneous PIC combines advantages of high-speed indium phosphide (InP) modulators and low-loss, high-contrast silicon nitride (Si<sub>3</sub>N<sub>4</sub>) arrayed waveguide gratings (AWGs)… (More)
Nanogel synthesis by RAFT polymerization is an emerging field for the control of architectures and functions of polymeric nanomaterials for bioapplications. In this Feature Article, we review the recent development in nanogel synthesis using preformed RAFT polymers and by direct RAFT polymerizations.