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A geometric active contour model without re-initialization for color images is proposed in this paper. It combines directional information about edge location based on local squared contrast as a part of driving force, together with the improved geodesic active contour containing Bayes error based statistical region information as well as an extra term that(More)
Controlled transfer of orbital angular momentum to an exciton-polariton Bose-Einstein condensate spontaneously created under incoherent, off resonant excitation conditions is a long-standing challenge in the field of microcavity polaritonics. We demonstrate, experimentally and theoretically, a simple and efficient approach to the generation of nontrivial(More)
The N-terminal tail domains of the core histones play important roles in gene regulation, but the exact mechanisms through which they act are not known. Recent studies suggest that the tail domains may influence the ability of RNA polymerase to elongate through the nucleosomal DNA and, thus, that posttranslational modification of the tail domains may(More)
In skeletal myoblasts, Ras has been considered to be a strong inhibitor of myogenesis. Here, we demonstrate that Ras is involved also in the chemotactic response of skeletal myoblasts. Expression of a dominant-negative mutant of Ras inhibited chemotaxis of C2C12 myoblasts in response to basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF),(More)
Chromatin readers decipher the functional readouts of histone modifications by recruiting specific effector complexes for subsequent epigenetic reprogramming. The LSD1 (also known as KDM1A) histone demethylase complex modifies chromatin and represses transcription in part by catalyzing demethylation of dimethylated histone H3 lysine 4 (H3K4me2), a mark for(More)
Formation of facultative heterochromatin at specific genomic loci is fundamentally important in defining cellular properties such as differentiation potential and responsiveness to developmental, physiological, and environmental stimuli. By the nature of their formation, heterochromatin and repressive histone marks propagate until the chain reaction is(More)
BACKGROUND To understand the involvement of structural maintenance of chromosome 4 (SMC4) in the development and progression of hepatocellular carcinoma (HCC). METHODS Real-time quantitative PCR and Western Blotting were applied to measure the expression of SMC4 in HCC samples and cell lines. The tumor-promoting effect of SMC4 was determined by WST-1,(More)
hSETD1A is a member of the trithorax (TrxG) family of histone methyltransferases (HMT) that methylate H3K4 at promoters of active genes. Although misregulation of mixed lineage leukemia (MLL) family proteins has been associated with acute leukemia, the role of hSETD1A in cancer remains unknown. In this study, we report that hSETD1A and its associated(More)
In this paper, we present a new variational formulation of geometric snake for image segmentation. Our formulation includes an internal energy term that penalizes the deviation of the level set function from a signed distance function and stopping term related to a particular segmentation of the image instead of gradient. They force the level set function(More)
Ontology heterogeneity is the primary obstacle for interoperation of ontology. Ontology mapping is the best way to solve this problem. In this paper, ontology heterogeneity and the current study situations of ontology mapping are discussed, and an ontology-mapping framework with a kind of hybrid architecture is put forward. An example of ontology mapping is(More)