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Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.
Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (= Lycopodium serratum ) in minuscule amounts. The most efficient total synthesis of huperzineExpand
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Asymmetric total synthesis of Lycopodium alkaloids α-obscurine, N-desmethyl-α-obscurine, β-obscurine and N-desmethyl-β-obscurine
The asymmetric total synthesis of α-obscurine (1), β-obscurine (2), N-desmethyl-α-obscurine (3), and N-desmethyl-β-obscurine (4) was accomplished. Key reactions in the construction of the A/B/C-ringExpand
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Isoselective ring-opening polymerization and asymmetric kinetic resolution polymerization of rac-lactide catalyzed by bifunctional iminophosphorane–thiourea/urea catalysts
A series of iminophosphorane–thiourea/urea bifunctional catalysts was synthesized and utilized for the isoselective ring-opening polymerization of rac-lactide. The ROPs were promoted efficiently,Expand
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Concise asymmetric total synthesis of (−)-patchouli alcohol
The asymmetric total synthesis of (−)-patchouli alcohol was accomplished in a concise manner. Key reactions include a highly diastereo- and enantioselective formal organocatalytic [4 + 2]Expand
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Chiral 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)-Catalyzed Stereoselective Ring-Opening Polymerization of rac-Lactide: High Reactivity for Isotactic Enriched Polylactides (PLAs)
Chiral 4,8-diphenyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (DiPh-TBD) was synthesized and applied to a ring-opening polymerization of rac-lactide (rac-LA). The chiral DiPh-TBD promoted the synthesis ofExpand
Phosphoric acids catalyzed asymmetric kinetic resolution polymerization of benzyl substituted ε-caprolactones: Efficient protocol for stereogradient polycaprolactones
Abstract An asymmetric kinetic resolution polymerization (AKRP) of 2-benzyl-e-caprolactone (2-BnCL) and 6-benzyl-e-caprolactone (6-BnCL) has been developed. Phosphoric acids catalyze the ring-openingExpand