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Mutations in the MeCP2 gene cause Rett syndrome, a neurologic condition affecting primarily young girls. To gain insight into the normal function of MeCP2, we examined its temporal and spatial expression patterns, and immunoreactive prevalence, during late embryonic and perinatal brain development. MeCP2 mRNA was detected in most regions of the developing(More)
In integrating CAD and CAM applications, one major problem is how to interpret CAD information in a manner that makes sense for CAM. Our goal is to develop a general approach that can be used with a variety of CAD and CAM applications for the manufacture of machined parts. In particular, we present a methodology for taking a CAD model, extracting(More)
  • Dana S Nau, Satyandra K Gupta, Mechanical Engr, Dept, Thomas R Kramer, William C Regli +1 other
  • 1993
One missing link between CAD and CAM is the lack of a systematic methodology for generating and evaluating alternative ways to manufacture a proposed design. To address this problem, we are developing a systematic approach for generating and evaluating alternative ways to manufacture machined parts, in order to provide information to the designer about the(More)
Using subtractive hybridization screening, the methyl CpG-binding domain containing protein MBD3 was identified as being more prevalently expressed in the embryonic brain than in the adult. In this report, we present the mRNA and protein expression patterns of MBD3 in the developing brain. MBD3 expression was detected in neuroepithelial cells of the(More)
This chapter describes a methodology for analyzing some of the manu-facturability aspects of machined parts during the design stage of the product development cycle, so that problems related to machining can be recognized and corrected while the product is being designed. Starting with the CAD design for a proposed part, our basic approach is to(More)
A method is presented to evaluate the workspace variation of a Stewart platform based machine tool. Three sets of constraints, covering strut lengths, platform and base spherical joint angles, and strut collisions, are formulated using inverse kinematics. Recognizing the need to vary the platform orientation during machining, an algorithm to efficiently(More)
Previous imaging studies have indicated that the levels of the dopamine transporter (DAT) are reduced in the brains of heroin users. However, whether these changes can be reversed by abstinence and/or treatment remains unclear. This study aims to investigate DAT availability in heroin users and changes in DAT availability after abstinence and treatment with(More)
Rett syndrome is a pediatric neurological condition that affects primarily girls. Approximately 30% of Rett syndrome cases arise from point mutations that introduce a premature stop codon into the MECP2 gene. Several studies have now shown that certain aminoglycosides can facilitate read-through of some types of nonsense mutations in a context-dependent(More)
This paper presents the development of a mathematical model describing the stiffness of a Stewart-platform-based milling machine. Matrix structural analysis is used to derive the stiffness matrix for each of the elements in the model and assemble them into a system-wide stiffness matrix. By incorporating the inverse kinematics of the machine tool, the(More)
In this study, we investigated whether transient cerebral ischemia affects the function and molecular expression of specific muscarinic cholinergic receptors. Our results show that in contrast to the GABA-B and A1 adenosine receptor systems, the ability of muscarinic receptors to attenuate evoked excitatory responses at vulnerable CA1 synapses is(More)