Guangming Xu

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OBJECTIVE The aim of this study is to evaluate clinical data from a large cohort of acromegalic patients with and without hyperprolactinemia. DESIGN AND METHODS Between January 2002 and June 2010, a set of data on 279 acromegalic patients undergoing transsphenoidal surgery was available. Based on preoperative GH and prolactin (PRL) levels, patients were(More)
The transsphenoidal approach is currently considered the preferred first-line treatment for pituitary adenoma. With the discovery and application of the pseudocapsule surrounding a pituitary adenoma, transsphenoidal surgery of pituitary adenoma further falls into two categories: “extracapsular” and traditional “intracapsular” resection methods, on the basis(More)
MDR (multidrug-resistance) represents a major obstacle to successful cancer chemotherapy and is usually accomplished by overexpression of P-gp (P-glycoprotein). Much effort has been devoted to developing P-gp inhibitors to modulate MDR. However, none of the inhibitors on the market have been successful. 1416(More)
Context Little systematic data on male prolactinomas treated with surgery are available. Objective To clarify the clinical features and confirm the efficacy of transsphenoidal surgery for male prolactinomas and predictive factors after initial surgery. Patients and methods This retrospective study included 87 male patients with prolactinoma treated by(More)
Gliomas are the most common type of primary tumor in the central nervous system and are characterized by abundant capillary angiogenesis. It is important to study the underlying molecular mechanisms of angiogenesis in order to aid the identification of potential therapeutic targets. The aim of the current study was to investigate the expression levels of(More)
The pituitary is responsible for multiple homeostatic functions including metabolism, growth and reproduction. Proteome analysis offers an efficient approach for a comprehensive analysis of pituitary protein expression. The pituitary is usually acquired from postmortem specimens, which may potentially affect the proteome profile by proteolysis. The aim of(More)
Pneumocephalus has been reported to have many causes. To our knowledge, a case of tension pneumocephalus caused by subarachnoid-esophagus fistula has not been reported previously. In this report, an unusual case of tension pneumocephalus, which appeared after esophageal cancer disrupting paravertebral tissue resulted in subarachnoid-esophagus fistula, is(More)
CD147, a transmembrane glycoprotein member of the immunoglobulin superfamily of receptors, is involved in invasion and angiogenesis of some types of tumors; but its roles and clinicopathologic significance in pituitary adenomas are not clear. Using immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction, we measured the(More)
To improve the achievable rate for the MIMO channels, we propose a hybrid transmission (HT) scheme that mixes half-duplex decode-and-forward cooperative relaying transmission (DFRH)with direct transmission (DT). In the HT scheme, the source message is divided into two parts: one is transmitted by DFRH scheme and another is transmitted by DT scheme.(More)
Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb repressive complex 2, which epigenetically represses genes involved in tumorigenesis and is highly expressed in tumors. However, no studies have investigated EZH2 expression and its clinical significance in human pituitary adenomas (PAs). Therefore, we examined the expression pattern(More)