Guangming Huang

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Lymphotoxin (LT)alpha is expressed by activated T cells, especially CD4(+) T helper type 1 cells, and by activated B and natural killer cells, but the functions of this molecule in vivo are incompletely defined. We have previously shown that follicular dendritic cell (FDC) clusters and germinal centers (GCs) are absent from the peripheral lymphoid tissues(More)
LT ␣-deficient (LT ␣ ϪրϪ) mice show altered splenic microarchitecture. This includes loss of normal B cell–T cell compartmentalization, of follicular dendritic cell (FDC) clusters, and of ability to form germinal centers (GC). LT ␣ ϪրϪ mice immunized with sheep red blood cells (SRBC) produced high levels of antigen-specific IgM but no IgG in either primary(More)
Ciliated airway epithelial cells are critical for mucosal barrier function, including host defense against pathogens. This cell population is often the primary target and thereby the first line of defense against many common respiratory viruses. It is also the precursor for mucous cells and thereby promotes mucociliary clearance of infectious and other(More)
Enhancing the response to interferon could offer an immunological advantage to the host. In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and transduced human cells. We found that the improvement(More)
Long noncoding RNAs (lncRNAs) are aberrantly expressed in various cancers. Although lncRNA GAS5 (growth arrest-specific transcript 5) has been characterized as a tumor suppressor in some kinds of cancer, its role and function in hepatocellular carcinoma (HCC) remain unknown. The present report demonstrates that there are lower levels of GAS5, PDCD4, and(More)
BACKGROUND AND STUDY AIMS Placement of a tube through the anus into the cecum has not yet been established as a method of administering whole-colonic treatment. The aim of this study was to evaluate the safety, feasibility, and value of transendoscopic enteral tubing (TET) for fecal microbiota transplantation (FMT) through the colon. PATIENTS AND METHODS(More)
Emerging evidences have shown that decorin expression is significantly reduced in many cancer tissues and cancer cells. However, its biological role and clinical significance in cholangiocarcinoma development and progression are unknown. In this study, immunohistochemistry was conducted to investigate the expression of decorin in cholangiocarcinomas. The(More)
Migration velocity of cell populations in vitro is one of important measurements of cell behaviors. As there are massive amount of cells in one image that share similar characteristics and are highly deformable, it is often computational expensive to track every individual cell. It is also difficult to track cells over a long period of time due to(More)
—In this paper, the exact closed-form capacity expression for a hybrid selection/MIMO (H-S/MIMO) system in the spatial correlated Rayleigh fading channels is investigated. There are two assumptions in this work. One is that the antenna selection at the transmitter is based on the criterion that maximizes the received signal power and only one transmit(More)
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