Guangcun Liu

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Controlled self-assembly of amphiphilic cyclodextrin is always a challenging topic in the field of supramolecular chemistry, since it provides the spontaneous generation of well-defined aggregation with functional host sites with great potential applications in drug-carrier systems. β-Cyclodextrin modified with an anthraquinone moiety (1) was successfully(More)
Camptothecin, as an antitumor drug, has shown significant antitumor activity against various cancers through the inhibition of topoisomerase I. However, its poor solubility severely limits the clinical applications. Here, we report a camptothecin supramolecular vesicle based on the host-guest interactions, which can uniformly disperse camptothecin into(More)
An enzymic method to protect selected amino group of lysine has been reported. This reaction proceeds smoothly under room temperature with high regioselectivity (up to 99%) and high yields (up to 90%). This work will pave the way for simple and selective protection of amino group of lysine in industry.
A class of aza-arm modified β-cyclodextrins were found to be able to trap paclitaxel (PTX), an effective but strongly hydrophobic anticancer drug, to form novel "supramolecular amphiphiles", which can further self-assemble into vesicular structures in aqueous solution. The obtained vesicles were characterized in detail by transmission electron microscopy(More)
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