Guangbin Qiu

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Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancies in the head and neck region. Recently, aberrantly expressed high-mobility group box 1 (HMGB1) has received a great deal of attention as a potential biomarker for cancer diagnosis and prognosis. Therefore, the aim of this study was to estimate HMGB1 levels in serum in LSCC(More)
OBJECTIVE To determine whether serum paraoxonase (PON) and arylesterase (ARE) activity might predict sepsis mortality. METHODS Patients with sepsis and healthy control subjects were enrolled in this retrospective study. Serum PON and ARE activity levels were measured. Patients were stratified according to 30-day mortality rates. RESULTS Serum PON and(More)
OBJECTIVE To identify and characterize laryngeal cancer related novel genes located on chromosome 6q25. METHODS Electric hybridization was performed in human genome database using EST (expression sequence tag) as probe. Novel genes were deduced by software from positive DNA clones and their cDNAs were amplified by RT-PCR using primers designed according(More)
Azole resistance in Aspergillus fumigatus has emerged as a worldwide public health problem. We sought here to demonstrate the occurrence and characteristics of azole resistance in A. fumigatus from different parts of China. A total of 317 clinical and 144 environmental A. fumigatus isolates from 12 provinces were collected and subjected to screening for(More)
Congenital heart diseases (CHDs) are the most common birth defects due to abnormal cardiac development. The T-box 20 (TBX20) gene is a member of the T‑box family of transcription factors and encodes TBX20, which is essential for early heart development. In the present study, reduced TBX20 expression was observed in CHD tissue samples compared with normal(More)
OBJECTIVE To study the expression and mechanism of WNK4 gene regulated by aldosterone. METHODS Wistar rats were treated with aldosterone and potassium water. Serum aldosterone and ion as well as urine ion were measured. The expression of WNK4 gene in kidney tissues was detected by real-time PCR. Kidney-derived HEK293 cells were cultured, transfected with(More)
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