GuangYuan Yu

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MicroRNAs (miRNAs) are a class of highly conserved, single-stranded RNA molecules (length, 18-25 nt) that regulate the expression of their target mRNAs. Previous studies have demonstrated that miRNAs may be novel biomarkers in the diagnosis of certain diseases. In order to evaluate the diagnostic value of miRNAs in childhood tuberculosis (TB), the(More)
Objective To investigate the expressions of miR-125b and target gene Raf1 proto-oncogene serine/threonine protein kinase (RAF1) in peripheral blood mononuclear cells (PBMCs) of pediatric patients with pulmonary tuberculosis (PTB), and observe the regulation of miR-125b on macrophage apoptosis and activity. Methods PBMCs of patients with PTB and healthy(More)
In this paper, we will consider the computation of objective function values when a nondominated frontier is searched in multiple objective quadratic-linear programming (MOQLP). Reference directions and weighted-sums constitute a methodological basis for the search. This idea leads to a parametric linear complementarity model formulation. A critical task of(More)
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