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Steroidal saponins from Solanum nigrum.
Six new steroidal saponins, solanigrosides C-H (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of Solanum nigrum. Their chemical structures were elucidated…
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Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.
Three unique pyrano[4,3-c][2]benzopyran-1,6-dione derivatives and a new furo[3,2-c]pyran-4-one, named phelligridins C-F (2-5), together with hispolon (8), (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one…
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Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert.
TLDR
Bioassay-guided fractionation of a cytotoxic EtOAc extract of Aspergillus flavipes occurring in the rhizosphere of Ericameria laricifolia resulted in the isolation of three new cytochalasans, which exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity.
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A new triterpenoid from the fruits of Gardenia jasminoides var. radicans Makino
TLDR
A novel triterpenoid isolated from the fruits of Gardenia jasminoides var.
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Ergosterols from the Culture Broth of Marine Streptomyces anandii H41-59
An actinomycete strain, H41-59, isolated from sea sediment in a mangrove district, was identified as Streptomyces anandii on the basis of 16S rDNA gene sequence analysis as well as the investigation…
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Indole Alkaloids from Alocasia macrorrhiza.
Five new indole alkaloids, alocasins A-E (3-7), together with known hyrtiosin B (1) and hyrtiosulawesin (2) were isolated from Alocasia macrorrhiza (L.) SCHOTT; their structures were elucidated on…
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Triterpenoid saponins from the root bark of Schima superba and their cytotoxic activity on B16 melanoma cell line.
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EM23, A Natural Sesquiterpene Lactone from Elephantopus mollis, Induces Apoptosis in Human Myeloid Leukemia Cells through Thioredoxin- and Reactive Oxygen Species-Mediated Signaling Pathways
TLDR
Mechanistic studies indicated that EM23 caused a marked increase in the level of reactive oxygen species (ROS) and Pretreatment with N-acetyl-L-cysteine, a ROS scavenger, almost fully reversed EM23-mediated apoptosis, providing important insights into the anticancer activities of the EM component EM23 against human CML K562 cells and AML HL-60 cells.
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A new biflavonoid with antiviral activity from the roots of Wikstroemia indica
A new biflavonoid, 4′-methoxydaphnodorin E, was isolated from the antiviral fraction of Wikstroemia indica against respiratory syncytial virus (RSV). Its structure was determined on the basis of…
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Antimycins A19 and A20, two new antimycins produced by marine actinomycete Streptomyces antibioticus H74-18
TLDR
Two new antimycin antibiotics were isolated from a cultured broth of marine actinomycete Streptomyces antibioticus H74-18 together with antimycins A1a and A1b, and showed potential antifungal activities against Candida albicans with MIC of about 5–10 μg ml–1.
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