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BACKGROUND Although radiological features of pneumocystis pneumonia (PCP) in non-Acquired Immune Deficiency Syndrome (AIDS) immunocompromised patients have been reported by other authors, there were no studies on the radiological stages of PCP previously. This study aimed to elucidate the radiological stages and prognoses of PCP in non-AIDS(More)
BACKGROUND 5-Hydroxytryptamine (5-HT) is a common neurotransmitter in the brain which plays an important role in the pathogenesis of sleep apnea. Dysfunction of 5-HT and 5-HT(2) receptors may lead to the collapse of the upper airway and the instability of respiratory control, which in turn produce apnea. Genioglossus (GG) is one of the most important(More)
BACKGROUND Fibrosing mediastinitis (FM) is a rare disease. FM is thought to be related to prior granulomatous mediastinal infection, such as histoplasmosis or tuberculosis. The majority of cases have been reported in endemic regions for histoplasmosis. The characteristics of cases of FM in China, where the prevalence of tuberculosis is high, have not been(More)
BACKGROUND The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. METHODS We enrolled 1003 residents aged 57.96 ± 8.99 years living in the Shichahai Community in(More)
Extracellular pH (pHe) and intracellular pH (pHi) are important factors for the excitability of chemosensitive central respiratory neurons that play an important role in respiration and obstructive sleep apnea. It has been proposed that inhibition of central Na+/ H+ exchanger 3 (NHE-3), a key pHi regulator in the brainstem, decreases the pHi, leading to(More)
OBJECTIVE To evaluate the effects of 5-HT2 agonist/antagonist Ketanserin on sleep apnea in Sprague-Dawley (SD) rats. METHODS Twenty adult male SD rats were operated for implantation of EEG and EMG electrodes and a microinjection probe was placed within the fourth ventricle. After recovery for a week, rats were monitored for sleep and respiration in three(More)
The cloned TWIK-related acid-sensitive K(+) channel (TASK-1) is sensitive to the pH changes within physiological pH range (pK~7.4). Recently, the native TASK-1-like channel was suggested to be the main contributor to the background (or leak) K(+) conductance in the motoneurons of the brain stem. Serotonin (5-HT) and variation of pH value in perfused(More)
OBJECTIVE To investigate the role of the TWIK-related acid-sensitive K(+) channel-1 (TASK-1) in the occurrence of sleep apnea. METHODS Brain and muscle electrodes were put on 27 SD rats to monitor the apneic episodes. Then the rats were killed with their brains taken out. Western blotting was used to examine the expression of TASK-1 as well as its family(More)
AIM To devise a new method for testing the animal model of sleep apnea syndrome (SAS). METHODS We simultaneously monitoring the respiratory wave through a micro-pressure transducer and the electrical signals of both electrocorticogram (ECoG) and electromyogram (EMG), for detecting the sleep-wake states and the respiratory rhythm in rats. The recording(More)
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