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Mechanisms of modulation of brain microvascular endothelial cells function by thrombin
Curcumin enhances the anticancer effects of trichostatin a in breast cancer cells
It is concluded that p53 independent apoptosis induced by combining curcumin and TSA involves JNK activation, providing a rationale for exploring the potential benefits of the combination ofCurcumin with TSA for treatment of breast cancer.
Nexrutine Inhibits Survival and Induces G1 Cell Cycle Arrest, Which Is Associated with Apoptosis or Autophagy Depending on the Breast Cancer Cell Line
Nexrutine is proposed to provide a novel approach for protection against breast cancer by decreasing the activities of 2 potential targets of breast cancer, cyclooxygenase (COX)-2, and peroxisome proliferators activated receptor gamma (PPARγ).
Effect of fenofibrate on diabetic retinopathy in rats via SIRT1/NF-κB signaling pathway.
- N. Chen, K. Jiang, Guang Yan
- Biology, MedicineEuropean review for medical and pharmacological…
- 1 October 2019
Fenofibrate facilitates the expression of SIRT1 in the retinal tissues to reduce the NF-κB activity, thereby treating DR in rats.
Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway
- Qi Zhang, Li-qun Hu, Hong-qi Li, Jun Wu, Na-na Bian, Guang Yan
- Biology, MedicineThe Korean journal of physiology & pharmacology…
- 15 February 2019
Results indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.
Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer
- S. Lanza-Jacoby, Guang Yan, G. Radice, Christopher LePhong, J. Baliff, R. Hess
- Biology, MedicineExperimental biology and medicine
- 1 July 2013
This is the first study to show in LSL-KrasG12D; Pdx-1/Cre mice that ICR and CCR delay the progression of lesions to PDA.
G protein‐coupled estrogen receptor‐mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells
- Joseph B. Altmann, Guang Yan, Jeffrey F Meeks, M. Abood, E. Brǎiloiu, G. Brailoiu
- BiologyJournal of neurochemistry
- 1 June 2015
The mechanisms underlying GPER‐mediated effects in RBMVEC with implications for the effect of estrogen on cerebral microvasculature are unraveled and atomic force microscopy studies revealed that G‐1 increased the modulus of elasticity, indicative of cytoskeletal changes and increase in R BMVEC stiffness.
(−)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of β1 adrenoceptor via GRK2 in experimental heart failure
EGCG has therapeutic effects on the heart function of HF rats and the mechanism might be related to the inhibition of the transfer membrane of GRK2 and to the reduction of the desensitization of β1-AR.
Celecoxib combined with atorvastatin prevents progression of atherosclerosis.
Catechin ameliorates cardiac dysfunction in rats with chronic heart failure by regulating the balance between Th17 and Treg cells
Oral administration of catechin effectively suppressed abdominal aorta ligation-induced CHF in rats, which was closely associated with its modulation on Th17 and Treg.