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Arabidopsis thaliana Protein Interactome Database (AtPID) is an object database that integrates data from several bioinformatics prediction methods and manually collected information from the literature. It contains data relevant to protein-protein interaction, protein subcellular location, ortholog maps, domain attributes and gene regulation. The predicted(More)
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) have been involved in the risk of hepatocellular carcinoma (HCC). However, the interactive effect of GSTM1 and GSTT1 has not been reported previously. The aim of this work was to investigate the interaction and synergism of their variants. We identified nine publications including 1,085 cases and 2,396(More)
This paper presents a data-driven method for the task of fault detection in nonlinear systems. In the proposed approach, locally weighted projection regression (LWPR) is employed to serve as a powerful tool for modeling the nonlinear process with locally linear models. In each local model, partial least squares (PLS) regression is performed and PLS-based(More)
Partial least squares (PLS) is an efficient tool widely used in multivariate statistical process monitoring. Since standard PLS performs oblique projection to input space X, it has limitations in distinguishing quality-related and quality-unrelated faults. Several postprocessing modifications of PLS, such as total projection to latent structures (T-PLS),(More)
DNA hypermethylation of secreted frizzled-related protein 2 (SFRP2) gene associated with the Wnt signaling pathway has been studied previously. However, the risk size and changing rules between colorectal cancer (CRC) and SFRP2 hypermethylation from precancerous disease to CRC remain unclear. The aim of work was therefore to investigate the risk size and(More)
Effective management of data is a major issue in genomics. Genomics data consists of highly interrelated information about genes, proteins, patterns, classifications, and interactions. Graph databases, which model graphs or networks of data, seem a natural way to manage genomics data. Graph databases can support visualization of both queries and results by(More)
BACKGROUND The data of MARCH (Metformin and AcaRbose in Chinese as the initial Hypoglycaemic treatment) trial demonstrated that acarbose and metformin have similar efficacy as initial therapy for hemoglobin A1c (HbA1c) reduction in Chinese patients with newly diagnosed type 2 diabetes. We investigated whether the therapeutic efficacy was diversified under(More)
OBJECTIVES To evaluate the association of coronary artery endothelial function and plasma levels of low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in patients with Type 2 Diabetes Mellitus (DM). METHODS We investigated 90 participants from our institution between October 2007 to March 2010: non-DM (n = 60) and(More)