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Osteosarcoma is a bone cancer that develops commonly in children and adolescents. However, osteosarcoma treatments often fail by the development of chemoresistance to apoptosis, and the molecular mechanisms remain unclear. In this study, we propose that autophagy is responsible for osteosarcomatous resistance to apoptosis. We implicate PERK-mediated(More)
The onset of lipid peroxidation within cellular membranes is associated with changes in their physiochemical properties and enzymatic dysfunction of the membrane environment. There are increasing bodies of evidence indicating that aldehydic molecules generated endogenously during the process of lipid peroxidation are causally involved in most of the(More)
The dynamics of the local field neural networks have been studied extensively, and many good results have been obtained. It should be pointed out that, the global robust stability for the static neural networks with time-delays received very little attention despite its practical importance. In this paper, by using the topological degree theory M-matrix(More)
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