Guang-Kui Xu

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Cells sense and respond to the elasticity of extracellular matrix (ECM) via integrin-mediated adhesion. As a class of well-documented mechanosenors in cells, integrins switch among inactive, bound, and dissociated states, depending upon the variation of forces acting on them. However, it remains unclear how the ECM elasticity directs and affects the states(More)
Tumor tissues often have a pH value lower than normal tissues, and this difference suggests a promising way of targeted cancer therapy by using pH-controlled drug delivery systems. On the basis of the mean-field theory, we present a theoretical methodology to predict the self-assembly and disassembly of pH-responsive polymers and nanoparticles in an ionic(More)
Using the linear stability analysis method, we investigate the surface wrinkling of a thin polymer coating on a cylinder in an externally applied electric field. It is demonstrated that energy competition between surface energy, van der Waals interactive potential energy and electrostatic interaction energy may lead to ordered patterns on the film surface.(More)
Adhesion processes of biological membranes that enclose cells and cellular organelles are essential for immune responses, tissue formation, and signaling. These processes depend sensitively on the binding constant K2D of the membrane-anchored receptor and ligand proteins that mediate adhesion, which is difficult to measure in the "two-dimensional" (2D)(More)
The adhesion of biological membranes is mediated by the binding of membrane-anchored receptor and ligand proteins. Central questions are how the binding kinetics of these proteins is affected by the membranes and by the membrane anchoring of the proteins. In this article, we (i) present detailed data for the binding of membrane-anchored proteins from(More)
Cell adhesion plays a pivotal role in various biological processes, e.g., immune responses, cancer metastasis, and stem cell differentiation. The adhesion behaviors depend subtly on the binding kinetics of receptors and ligands restricted at the cell-substrate interfaces. Although much effort has been directed toward investigating the kinetics of adhesion(More)
Self-assembled nanostructures of amphiphilic block copolymers hold great promise for applications in nanomedicine. Blending polymers provides an effective way to produce multifunctional drug delivery vesicles at micro- and nanoscales. Here we investigate the self-assembly of homopolymer and diblock copolymer blends in a selective solvent by using the(More)
Deciphering the mechanisms underlying the high sensitivity of cells to mechanical microenvironments is crucial for understanding many physiological and pathological processes, e.g., stem cell differentiation and cancer cell metastasis. Here, a cytoskeletal tensegrity model is proposed to study the reorientation of polarized cells on a substrate under(More)
The atomic force microscopy (AFM) has been widely used to measure the mechanical properties of biological cells through indentations. In most of existing studies, the cell is supposed to be linear elastic within the small strain regime when analyzing the AFM indentation data. However, in experimental situations, the roles of large deformation and surface(More)
Adhesions between neighboring cells or between cells and their surrounding tissue/matrix play a crucial role in a wide range of biological processes. In order to investigate the competitive mechanisms between cell-cell and cell-matrix adhesions, we here develop a theoretical framework for multiple interacting cells lying on a planar matrix coated with(More)