Guang Jun Zhang

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By SHAOCHENG XIE1¤ , KUAN-MAN XU2, RICHARD T. CEDERWALL1, PETER BECHTOLD3, ANTHONY D. DEL GENIO4, STEPHEN A. KLEIN5, DOUGLAS G. CRIPE6, STEVEN J. GHAN7, DAVID GREGORY8, SAM F. IACOBELLIS9 , STEVEN K. KRUEGER10, ULRIKE LOHMANN11, JON C. PETCH12 , DAVID A. RANDALL6, LEON D. ROTSTAYN13, RICHARD C. J. SOMERVILLE9, YOGESH C. SUD14, KNUT VON SALZEN15, GREGORY K.(More)
[1] The secondary meridional circulation induced by convective momentum transport (CMT) within the ascending branch of the Hadley circulation is a missing dynamical mechanism that can cause common failure of general circulation models (GCMs) in simulating seasonal migration of the intertropical convergence zone (ITCZ) precipitation maximum across the(More)
The Hedgehog (Hh) pathway regulates cell differentiation and proliferation during development by controlling the Gli transcription factors. Cell fate decisions and progression toward organ and tissue maturity must be coordinated, and how an energy sensor regulates the Hh pathway is not clear. AMP-activated protein kinase (AMPK) is an important sensor of(More)
Shaocheng Xie, Minghua Zhang, Mark Branson, Richard T. Cederwall, Anthony D. Del Genio, Zachary A. Eitzen, Steven J. Ghan, Sam F. Iacobellis, Karen L. Johnson, Marat Khairoutdinov, Stephen A. Klein, Steven K. Krueger, Wuyin Lin, Ulrike Lohmann, Mark A. Miller, David A. Randall, Richard C. J. Somerville, Yogesh C. Sud, Gregory K. Walker, Audrey Wolf,(More)
Aneuploidy is one of the most common genetic alterations in cancer cell genomes. It greatly contributes to the heterogeneity of cancer cell genomes, and its roles in tumorigenesis are attracting more and more attentions. Zebrafish is emerging as a new genetic model for many human diseases including cancer. The zebrafish cancer model has shown an equivalent(More)
The original version of this Article contained an error in the title where: " KANK1 inhibits cell growth by inducing apoptosis though regulating CXXC5 in human malignant peripheral nerve sheath tumors ". Now reads: " KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors ". There were also(More)
BACKGROUND The mouse double minute 1 (Mdm1) gene was first reported and cloned in mouse tumor cell lines as an oncogene candidate. Later, it was found that mutation of Mdm1 might cause age-related retinal degeneration 2 in mice by genetic linkage analysis. Additionally, the MDM1 protein was found to be expressed in the centrosomes, cilia, and the nucleus of(More)
Currently, human cancer genomics is making great progress, and many mutations of new cancer driver genes have been detected at an unprecedented rate in a variety of human cancers. Many details of the genetic alterations in cancer cell genomes have been revealed by the massively parallel sequencing. Long-lasting aneuploidy caused large-scale somatic copy(More)
During boreal summer, convective activity over the eastern Pacific (EPAC) inter-tropical convergence zone (ITCZ) exhibits vigorous intraseasonal variability (ISV). Previous observational studies identified two dominant ISV modes over the EPAC, i.e., a 40-day mode and a quasi-biweekly mode (QBM). The 40-day ISV mode is generally considered a local expression(More)