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Cryptococcus gattii recently emerged as the causative agent of cryptococcosis in healthy individuals in western North America, despite previous characterization of the fungus as a pathogen in tropical or subtropical regions. As a foundation to study the genetics of virulence in this pathogen, we sequenced the genomes of a strain (WM276) representing the(More)
Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association between coffee consumption and CVD mortality among(More)
BES data on J/ψ → γ(KKππ) are presented. The KK̄ contribution peaks strongly near threshold. It is fitted with a broad 0 resonance with mass M = 1800 ± 100 MeV, width Γ = 500 ± 200 MeV. A broad 2 resonance peaking at 2020 MeV is also required with width ∼ 500 MeV. There is further evidence for a 2 component peaking at 2.55 GeV. The non-KK̄ contribution is(More)
We investigated the associations of type 2 diabetes and a history of myocardial infarction (MI) with coronary heart disease, stroke, cardiovascular and total mortality, and whether these effects are different in men and women. Study cohorts included 51,735 Finnish men and women aged 25–74 years. Smoking status and the history of MI and type 2 diabetes were(More)
The aim of this study was to compare the magnitude of the effect of diabetes and stroke at baseline and during follow-up on risk of stroke mortality. Study cohorts included 25,155 Finnish men and 26,423 women aged 25–74 years. Data on diabetes and stroke history at baseline, their incidence during follow-up, and stroke death were obtained from national(More)
No previous studies on the association between salt intake and the risk of type 2 diabetes have been reported. The aim of this study was to assess whether high salt intake, measured by 24-h urinary sodium excretion, is an independent risk factor for type 2 diabetes. We followed prospectively 932 Finnish men and 1,003 women aged 35–64 years with complete(More)
Whole-cell patch-clamp recording from rat superior cervical ganglion neurons in culture was used to investigate the modulatory effect of desensitized α7-nAChRs on mAChRs. An inward α-bungarotoxin and methyllycaconitine sensitive current was elicited by rapid application of choline, which consisted of a fast and a slow desensitizing component. The amplitude(More)
Objective and design: TNF-α is a potent proinflammatory cytokine that plays an important role in immunity and inflammation, and in the control of cell proliferation, differentiation and programmed cell death. However, it is known that TNF-α is also the founding member of a still growing family of cytokines with diverse bioregulative functions. Its detailed(More)
Flash floods have occurred frequently in the urban areas of southern China. An effective process-oriented urban flood inundation model is urgently needed for urban storm-water and emergency management. This study develops an efficient and flexible cellular automaton (CA) model to simulate storm-water runoff and the flood inundation process during extreme(More)
A measuring system based on a resistive divider using a copper sulfate (CuSO4 solution) has been developed to measure high-voltage impulses with rise times of several tens of nanoseconds. The response and temperature characteristics of the resistive divider have been studied. The divider has excellent response characteristics (< 1-ns theoretical rise time)(More)