Grushenka Wolfgang

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Leptomeningeal carcinomatosis (LC) occurs in solid tumors like breast, lung carcinoma and melanoma, rarely sarcoma and in leukemia and lymphoma. Clinical symptoms of LC often present with differential diagnostic problems. The most common presentation are multiple neuraxis syndromes which for didactic reasons are classically considered as central nervous(More)
BACKGROUND & AIMS Interactions between C-C chemokine receptor types 2 (CCR2) and 5 (CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting monocyte/macrophage recruitment and tissue infiltration, as well as hepatic stellate cell activation. Cenicriviroc (CVC) is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against(More)
Bronchial asthma can be associated with Churg Strauss syndrome (CSS). A peripheral neuropathy may be the initial manifestation of CSS. There is also some evidence that leucotriene receptor antagonists (LTAs) may trigger CSS in asthmatic patients, especially when steroids are tapered previously. However, the pathogenesis is unclear and the association(More)
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