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Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.

• Grigory A. Efimov, Andrei A. Kruglov, +9 authors Sergei A. Nedospasov
• Proceedings of the National Academy of Sciences…
• 2016

Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti-TNF therapy. TNF is produced by a variety of cell types, and it can play… (More)

Tumor necrosis factor, lymphotoxin and cancer.

• Marina S. Drutskaya, Grigory A. Efimov, A. A. Kruglov, Dmitry V. Kuprash, Sergei A. Nedospasov
• IUBMB life
• 2010

Initially TNF has been discovered as an anti-tumor factor, but it is now considered as one of the universal effectors of innate signaling implicating its key role in host defense and inflammation.… (More)

Can we design a better anti-cytokine therapy?

• Marina S. Drutskaya, Grigory A. Efimov, Andrei A. Kruglov, Sergei A. Nedospasov
• Journal of leukocyte biology
• 2017

Cytokine neutralization is successfully used for treatment of various autoimmune diseases and chronic inflammatory conditions. The complex biology of the two well-characterized proinflammatory… (More)

Single-domain antibody-based ligands for immunoaffinity separation of recombinant human lactoferrin from the goat lactoferrin of transgenic goat milk.

• Sergei V. Tillib, M. E. Privezentseva, +6 authors Elena R. Sadchikova
• Journal of chromatography. B, Analytical…
• 2014

Single-domain antibody generation technology was applied to make new Sepharose-bound ligands for affinity separation of closely related proteins, such as human and goat lactoferrin. We generated… (More)

Modern anti-cytokine therapy of autoimmune diseases

• Irina V. Astrakhantseva, Grigory A. Efimov, Marina S. Drutskaya, A. A. Kruglov, Sergei A. Nedospasov
• Biochemistry (Moscow)
• 2014

The emergence of genetically engineered biological agents opened new prospects in the treatment of autoimmune and inflammatory diseases. Cytokines responsible for regulation of a wide range of… (More)

Methods for in vivo molecular imaging

• Anna A Kuchmiy, Grigory A. Efimov, Sergei A. Nedospasov
• Biochemistry (Moscow)
• 2012

Visualization of single molecules and specific subsets of cells is widely used for studies of biological processes and particularly in immunological research. Recent technological advances have… (More)

Modalities of experimental TNF blockade in vivo: mouse models.

• A. A. Kruglov, Alexi V. Tumanov, +7 authors Sergei A. Nedospasov
• Advances in experimental medicine and biology
• 2011

Tumor Necrosis Factor and the consequences of its ablation in vivo.

• Grigory A. Efimov, A. A. Kruglov, Sergey V Tillib, Dmitry V. Kuprash, Sergei A. Nedospasov
• Molecular immunology
• 2009

Although TNF has been discovered due to anti-tumor activity, its physiological functions are different. Current knowledge places TNF downstream of many receptors of innate immunity, implying its… (More)

[Interleukin-6 From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting].

• Marina S. Drutskaya, Maxim A. Nosenko, K-S N Atretkhany, Grigory A. Efimov, Sergei A. Nedospasov
• Molekuliarnaia biologiia
• 2015

Interleukin-6 (IL-6)--one of the most important pro-inflammatory cytokines that has a broad spectrum of immunoregulatory properties. Molecular mechanisms of signal transduction of IL-6 and its… (More)

VHH-Based Bispecific Antibodies Targeting Cytokine Production

• Maxim A. Nosenko, Kamar-Sulu N. Atretkhany, +5 authors Sergei A. Nedospasov
• Front. Immunol.
• 2017

Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess… (More)

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