Grete Anette Birkeland Kro

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OBJECTIVE To identify the distribution of carbon dioxide tension (pCO(2) ) relative to pH in validated umbilical cord acid-base data. DESIGN Observational study. SETTING European hospital labour wards. POPULATION Data for 36,432 term newborns were obtained from three sources: two trials of fetal monitoring with electrocardiography (ECG; the Swedish(More)
BACKGROUND Early detection of hypoxic-ischemic (HI) injury in the asphyxic newborn is important because present prognostic factors are inadequate. Furthermore, therapeutic interventions may have additional benefit if initiated in time. PURPOSE To assess whether the use of a combined protocol including conventional magnetic resonance imaging (MRI),(More)
BACKGROUND Global hypoxia may affect regions of the neonatal heart during systole and diastole differently. OBJECTIVE In the first study, the aim was to assess longitudinal myocardial function in newborn pigs during global hypoxia and recovery. In the second study, invasive hemodynamic data were evaluated and compared with tissue velocities and(More)
AIM To assess the effect of time of active pushing (TAP) on neonatal outcome. MATERIALS AND METHODS The study population (n=36,432) was taken from a Swedish randomized control trial on intrapartum monitoring, a European Union fetal electrocardiogram trial, and from Mölndal Hospital. After validation of acid-base samples and TAP, 22,812 cases were accepted(More)
OBJECTIVE To determine the association between 5-min Apgar score and umbilical cord artery carbon dioxide tension (pCO₂). DESIGN Observational study. SETTING European hospital labor wards. POPULATION Data from 36,432 newborns ≥36 gestational weeks were obtained from three sources: two trials of monitoring with fetal electrocardiogram (the Swedish(More)
End-stage renal disease (ESRD) impairs drug metabolism via cytochrome P450 (CYP) 3A. However, it is unclear whether CYP3A activity recovers following kidney transplantation. Therefore, the aim of this study was to evaluate the change in CYP3A activity measured as 4β-hydroxycholesterol (4βOHC) concentration after kidney transplantation. In total, data from(More)
BACKGROUND Resuscitation with 100% oxygen increases oxidative stress and is detrimental for organ function. OBJECTIVE To study the effects of resuscitation with 100% oxygen compared to room-air on myocardial function. METHODS Twenty-eight newborn pigs underwent global hypoxia (8% oxygen/N2) until base excess reached -20 mmol/l. The animals were(More)
This study aimed to assess the effect of correcting for the impact of heart rate (HR) or ejection time (ET) on myocardial velocities in the long axis in piglets undergoing hypoxia. The ability to eject a higher volume at a fixed ET is a characteristic of contractility in the heart. Systolic velocity of the atrioventricular annulus displacement is directly(More)
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