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Visceral adiposity is associated with type-2-diabetes, inflammation, dyslipidemia and non-alcoholic fatty liver disease (NAFLD), whereas subcutaneous adiposity is not. We hypothesized that the link… Continue Reading
BackgroundFructose produces hepatic insulin resistance in humans and animals. We have proposed that the selective metabolism of fructose by the liver can, under conditions of elevated fructose… Continue Reading
Health workers in low-resource settings often lack the support and tools to follow evidence-based clinical recommendations for diagnosing, treating and managing sick patients. Digital technologies,… Continue Reading
White adipose tissue consists of adipocytes embedded in a connective tissue matrix and includes a well-organized vasculature and nerve supply. Though a principal feature of adipose tissue is to store… Continue Reading
Genetic ablation of mitofusin 2 (Mfn2) in mice results in ER stress and insulin resistance in the liver. In liver cells, saturated fatty acids (SFA) induce ER stress and activate c-Jun NH2 terminal… Continue Reading