Gregory S Yochum

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Defining the CREB Regulon A Genome-Wide Analysis of Transcription Factor Regulatory Regions

Soren Impey, Sean R. McCorkle, +7 authors Richard Goodman
Cell
2004

The CREB transcription factor regulates differentiation, survival, and synaptic plasticity. The complement of CREB targets responsible for these responses has not been identified, however. We… (More)

SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

Carol D. Laherty, Andrew N Billin, +10 authors Robert N. Eisenman
Molecular cell
1998

The transcriptional corepressor mSin3 is found in a large multiprotein complex containing the histone deacetylases HDAC1 and HDAC2, in addition to at least five tightly associated polypeptides. We… (More)

A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions.

Stefanie J Otto, Sean R. McCorkle, +7 authors Gail Mandel
The Journal of neuroscience : the official…
2007

The repressor element 1 (RE1) silencing transcription factor (REST) helps preserve the identity of nervous tissue by silencing neuronal genes in non-neural tissues. Moreover, in an epithelial model… (More)

Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split.

Gregory S Yochum, Donald E. Ayer
Molecular and cellular biology
2002

mSin3A and Transducin-Like Enhancer of Split (TLE) are two histone deacetylase (HDAC)-containing corepressors that function to repress transcription at targeted genes. Pf1 is a plant homeodomain zinc… (More)

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

Daniel Bottomly, Sydney L. Kyler, Shannon K. McWeeney, Gregory S Yochum
Nucleic acids research
2010

Deregulation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. Mutations in the adenomatous polyposis coli (APC) gene occur in the vast majority of colorectal cancers and are an… (More)

Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.

Gregory S Yochum, Donald E. Ayer
Molecular and cellular biology
2001

The mSin3A-histone deacetylase corepressor is a multiprotein complex that is recruited by DNA binding transcriptional repressors. Sin3 has four paired amphipathic alpha helices (PAH1 to -4) that are… (More)

A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression.

Gregory S Yochum, Ryan Cleland, Richard Goodman
Molecular and cellular biology
2008

Mutations in components of the Wnt signaling pathway initiate colorectal carcinogenesis by deregulating the beta-catenin transcriptional coactivator. beta-Catenin activation of one target in… (More)

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells.

Wesley M. Konsavage, Sydney L. Kyler, Sherri A. Rennoll, Ge Jin, Gregory S Yochum
The Journal of biological chemistry
2012

Mutations in the Wnt/β-catenin pathway occur in most colorectal cancers (CRCs), and these mutations lead to increased nuclear accumulation of the β-catenin transcriptional co-activator. In the… (More)

A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers.

Gregory S Yochum, Colette M Sherrick, Mary Macpartlin, Richard Goodman
Proceedings of the National Academy of Sciences…
2010

Aberrant MYC gene expression by the Wnt/beta-catenin pathway is implicated in colorectal carcinogenesis. Wnt/beta-catenin signaling stimulates association of the beta-catenin coactivator complex with… (More)

Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells.

Gregory S Yochum, Shannon K. McWeeney, Veena Rajaraman, Ryan Cleland, Sandra T. Peters, Richard Goodman
Proceedings of the National Academy of Sciences…
2007

Most instances of colorectal cancer are due to abnormalities in the Wnt signaling pathway, resulting in nuclear accumulation of beta-catenin. beta-Catenin activates transcription of target genes… (More)

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