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PURPOSE Panitumumab is a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody that improves progression-free survival (PFS) in chemotherapy-refractory metastatic colorectal cancer (mCRC). This trial evaluated the efficacy and safety of panitumumab plus fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone(More)
Each year from 1979 through 1983, 35 Angus bull calves were selected from a herd at the Eastern Ohio Resource Development Center to be individually fed in a 140-d postweaning performance test. From these 35 individually fed bulls, the three highest and three lowest for feed conversion (feed:gain) were selected and randomly mated to approximately 20 cows(More)
AIM To evaluate the efficacy and safety of selective internal radiation therapy (SIRT). MATERIALS AND METHODS A retrospective analysis was undertaken of all patients who underwent SIRT at a single institution. Diagnostic and therapeutic angiograms, computed tomography (CT) images, positron-emission tomography (PET) images, and planar isotope images were(More)
AIMS Variants in UGT1A1 have previously been associated with toxicity from irinotecan chemotherapy. We conducted a pragmatic prospective cohort study to establish the relevance of UGT1A1 variants in the prediction of severe diarrhea and neutropenia in patients with colorectal cancer receiving irinotecan in a routine clinical setting. MATERIALS & METHODS(More)
PURPOSE We evaluated the influence of RAS mutation status on the treatment effect of panitumumab in a prospective-retrospective analysis of a randomized, multicenter phase III study of panitumumab plus fluorouracil, leucovorin, and irinotecan (FOLFIRI) versus FOLFIRI alone as second-line therapy in patients with metastatic colorectal cancer (mCRC;(More)
A single generation divergent selection study, replicated four times (1983, 1984, 1985, and 1986), was conducted to assess genetic differences between progeny of high and low feed conversion sires in Angus beef cattle and to determine correlated response for weight gain (ADG140), feed intake (AVFD140), and BW (OFFTSTWT) in a time- (140-d) and fat-constant(More)
Acquired toxoplasmosis in children Sir, In their review of acquired toxoplasmosis in children, McNicholl and Flynn (Archives, 1978, 53, 414) suggest the use of sulphadimidine and pyrimethamine for treatment of generalised toxoplasmosis. We report a child with generalised toxoplasmosis who had a dramatic recovery after treatment with co-trimoxazole. An 1(More)