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- Gustavo Matute-Bello, Gregory P Downey, +4 authors Wolfgang Michael Kuebler
- American journal of respiratory cell and…
- 2011
Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main features of acute lung injury in animal models. A Committee was organized to determine the main features… (More)
- Francis X McCormack, Yoshikazu Inoue, +22 authors Bruce C. Trapnell
- The New England journal of medicine
- 2011
BACKGROUND
Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in women; it is associated with inappropriate activation of mammalian target of rapamycin (mTOR) signaling, which… (More)
- Warren L Lee, Gregory P Downey
- American journal of respiratory and critical care…
- 2001
Introduction Genetics of Elastase In vitro Substrates of Elastase—Clues to in vivo Function? Regulation and Function of Elastase Inhibition by and Evasion of Antiproteases Elastase Release by… (More)
- Michael Glogauer, Puneeta Kaur Arora, Duen-Suey Chou, Paul A. Janmey, Gregory P Downey, C A McCulloch
- The Journal of biological chemistry
- 1998
To survive in a mechanically active environment, cells must adapt to variations of applied membrane tension. A collagen-coated magnetic bead model was used to apply forces directly to the actin… (More)
- Warren L Lee, Gregory P Downey
- Current opinion in critical care
- 2001
Neutrophils are considered to be central to the pathogenesis of most forms of acute lung injury (ALI). For the sake of clarity, neutrophil involvement in ALI can be conceptualized as consisting of… (More)
- Michael Glogauer, Christophe C. Marchal, +7 authors David J Kwiatkowski
- Journal of immunology
- 2003
Defects in myeloid cell function in Rac2 knockout mice underline the importance of this isoform in activation of NADPH oxidase and cell motility. However, the specific role of Rac1 in neutrophil… (More)
- Léa Fialkow, Yingchun Wang, Gregory P Downey
- Free radical biology & medicine
- 2007
As a cornerstone of the innate immune response, neutrophils are the archetypical phagocytic cell; they actively seek out, ingest, and destroy pathogenic microorganisms. To achieve this essential role… (More)
Although both of the small Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 have been demonstrated to play a role in chemotaxis, the precise and possible unique roles performed by each of these… (More)
- George Scott Worthen, Birgit Schwab, Elliot L. Elson, Gregory P Downey
- Science
- 1989
The effect of peptide chemoattractants on neutrophil mechanical properties was studied to test the hypothesis that stimulated neutrophils (diameter, 8 micrometers) are retained in pulmonary… (More)
- Igor E. Konstantinov, S. Arab, +8 authors Andrew N Redington
- Physiological genomics
- 2004
Remote ischemic preconditioning (IPC) reduces tissue injury caused by ischemia-reperfusion (IR) in distant organs. We tested the hypothesis that remote IPC (rIPC) modifies inflammatory gene… (More)