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Melatonin—A pleiotropic, orchestrating regulator molecule
Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm.
Low levels of 5-HT agonism in the brain cortex may explain the severely pessimistic, dysfunctional attitudes associated with major depression.
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
Melatonin’s efficacy in combating free radical damage in the brain suggests that it can be a valuable therapeutic agent in the treatment of cerebral edema following traumatic brain injury or stroke.
Potential use of melatonergic drugs in analgesia: Mechanisms of action
MT(1) melatonin receptor in the human retina: expression and localization.
- J. Scher, E. Wankiewicz, Gregory M. Brown, H. Fujieda
- BiologyInvestigative ophthalmology & visual science
- 1 March 2002
The MT(1) receptor is expressed in diverse neuronal cell types in the human retina, providing evidence of a significant role for melatonin and this receptor subtype in human vision.
Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors
It is demonstrated that melatonin, through activation of different receptor subtypes, can exert opposite effects on the same substrate, suggesting that receptor subtype is the primary molecular basis for the diversity of melatonin effects.
Prospects of the Clinical Utilization of Melatonin
Melatonin is the major messenger of light-dependent periodicity, implicated in the seasonal reproduction of animals and pubertal development in humans, and one of the most powerful scavengers of free radicals.
Bidirectional communication between sleep and circadian rhythms and its implications for depression: Lessons from agomelatine
Measurement of melatonin in body fluids: Standards, protocols and procedures
- E. A. de Almeida, P. Di Mascio, S. Pandi-Perumal
- Medicine, BiologyChild's Nervous System
- 21 November 2010
Melatonin measurements are useful for evaluating problems related to the onset or offset of sleep and for assessing phase delays or advances of rhythms in entrained individuals, and their use being recommended for phase typing in patients suffering from sleep and mood disorders is recommended.
Can Melatonin Be a Potential “Silver Bullet” in Treating COVID-19 Patients?
Experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic is discussed and exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines.