Gregory Lyng

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Polychlorinated biphenyls (PCBs) are persistent environmental contaminants that are highly toxic to the developing nervous system, particularly via their disruption of dopamine (DA) function. In order to characterize the effects of PCBs on the developing basal ganglia DA system, we utilized an organotypic coculture system of developing rat striatum and(More)
Organotypic cocultures of striatum, cortex, and ventral mesencephalon were used to study the anatomical and physiological development of striatal neurons in the presence or absence of cortical and nigral (SN/VTA) inputs. Striatum and cortex were dissected from prenatal (E18-E22) or early postnatal (P0-P2) rats, and SN/VTA was dissected from E14-15 fetuses;(More)
Using organotypic co-cultures of rat embryonic day 14 (E14) ventral mesencephalon (VM) and E21 striatum, we have described the developmental changes in (i) dopamine (DA) neurochemistry; (ii) numbers of DA neurons; and (iii) protein expression of tyrosine hydroxylase (TH), DA transporter (DAT), and glutamic acid decarboxylase (GAD 65/67), over 17 days in(More)
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that have been demonstrated to be toxic to the dopamine (DA) systems of the central nervous system. One proposed mechanism for PCB-induced DA neurotoxicity is inhibition of the vesicular monoamine transporter (VMAT); such inhibition results in increased levels of unsequestered DA and(More)
It has long been a standard practice to neglect diffusive effects in stability analyses of detonation waves. Here, with the principal aim of quantifying the impact of these oft-neglected effects on the stability characteristics of such waves, we use numerical Evans-function techniques to study the (spectral) stability of viscous strong detonation(More)
We study the Gaussian semiclassical soliton ensemble, a collection of multisoliton solutions of the focusing nonlinear Schrödinger equation. The ensemble is generated by adding a particular asymptotically vanishing sequence of perturbations to Gaussian initial data. Recent results [Lee, Lyng, & Vankova (2012)] suggest that, remarkably, these(More)
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